Evidence map›Paper›PMID 37680710›Full record

ArticleFrontiers in pharmacology2023

Obesity exacerbates influenza-induced respiratory disease via the arachidonic acid-p38 MAPK pathway.

Ravishankar Chandrasekaran, Carolyn R Morris, Isabella M Butzirus, Zoe F Mark, Amit Kumar, Dhemerson Souza De Lima, Nirav Daphtary, Minara Aliyeva, Matthew E Poynter, Vikas Anathy and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Arachidonic acid metabolism in spinal cord injury.Journal of advanced research · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Ravishankar ChandrasekaranDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, United States.
Carolyn R MorrisDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, United States.
Isabella M ButzirusDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, United States.
Zoe F MarkPathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, United States.
Amit KumarPathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, United States.
Dhemerson Souza De LimaPathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, United States.
Nirav DaphtaryDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, United States.
Minara AliyevaDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, United States.
Matthew E PoynterDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, United States.
Vikas AnathyPathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, United States.
Anne E DixonDepartment of Medicine, Larner College of Medicine, University of Vermont, Burlington, VT, United States.
University of Vermont · US

Funding

Obese Allergic Asthma and the Impact of Weight Loss on Airway Epithelial FunctionR01HL133920 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI DIXON, ANNE E, POYNTER, MATTHEW E · 2016 to 2020
$3.9M
Mitochondrial Redox Perturbations in Obese Allergic AsthmaR01HL136917 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ANATHY, VIKAS, DIXON, ANNE E · 2018 to 2022
$3.6M
Endoplasmic Reticulum Stress Signaling in Allergen-induced Airway RemodelingR01HL122383 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ANATHY, VIKAS · 2015 to 2023
$3.5M
Ketone Body Supplementation in Obese AsthmaR01HL142081 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI POYNTER, MATTHEW E · 2018 to 2021
$1.8M
Unfolded protein response in Influenza virus infection and inflammationR01HL141364 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI ANATHY, VIKAS · 2019 to 2022
$1.6M
NHLBI NIH HHS R01 HL122383NHLBI NIH HHS R01 HL133920NHLBI NIH HHS R01 HL136917NHLBI NIH HHS R01 HL141364NHLBI NIH HHS R01 HL142081
6 · The paper itself

Abstract

Obesity is a risk factor for severe influenza, and asthma exacerbations caused by respiratory viral infections. We investigated mechanisms that increase the severity of airway disease related to influenza in obesity using cells derived from obese and lean individuals, and

Indexed as

arachidonic acidinfluenza A viruslung inflammationlung injuryobesityp38 MAPK

Identifiers

PMID37680710
PMCPMC10482034
OpenAlexW4386090680

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.