ArticleJournal of the American Chemical Society2023
Synthesis of (-)-Cotylenol, a 14-3-3 Molecular Glue Component.
Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
5 citing papers in PubMed.
- Article
- Enantioselective Total Synthesis of (+)-Fusicoccadiene via Photocatalytic Polyene Isomerization.Journal of the American Chemical Society · 2026Article
- Organocatalytic Enantioselective [4 + 4] Cycloadditions of Furan Ortho-Quinodimethanes.Angewandte Chemie (International ed. in English) · 2025Article
- Contrasteric Glycosylations of Cotylenol and 1,2-Diols by Virtual Linker Selection.Journal of the American Chemical Society · 2025Article
- Total biosynthesis of cotylenin diterpene glycosides as 14-3-3 protein-protein interaction stabilizers.Chemical science · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Small molecules that modulate the 14-3-3 protein-protein interaction (PPI) network represent valuable therapeutics and tool compounds. However, access has been lost to 14-3-3 PPI molecular glues of the cotylenin class, leading to investigations into the practical chemical syntheses of congeners and analogues. Here we report a concise synthesis of (-)-cotylenol via a 10-step asymmetric entry into a diversifiable 5-8-5 core. This route features a mild Liebeskind-Srogl fragment coupling that tolerates unprecedented steric hindrance to produce a highly congested ketone, and a tandem Claisen-ene cascade that establishes the 8-membered ring. Late-stage control of stereochemistry and functionality leads to (-)-cotylenol and sets the stage for focused library synthesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.