Evidence map›Paper›PMID 37684170›Full record

ArticleJournal of pediatric surgery2023

Hydrogen Sulfide Improves Outcomes in a Murine Model of Necrotizing Enterocolitis via the Cys440 Residue on Endothelial Nitric Oxide Synthase.

Chelsea E Hunter, Fikir M Mesfin, Krishna Manohar, Jianyun Liu, W Christopher Shelley, John P Brokaw, Anthony R Pecoraro, Brian D Hosfield, Troy A Markel

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Chelsea E HunterDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Fikir M MesfinDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Krishna ManoharDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Jianyun LiuDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
W Christopher ShelleyDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
John P BrokawDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Anthony R PecoraroDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Brian D HosfieldDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.
Troy A MarkelDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA; Riley Hospital for Children at Indiana University Health, Indianapolis, IN, USA. Electronic address: tmarkel@iupui.edu.
Indiana University School of MedicineIndiana University Health · US

Funding

Neonatal gut-on-a-chip platform for high content drug testing and precision medicineR01HD105301 · NICHD · WASHINGTON UNIVERSITY · PI GOOD, MISTY L, MAGNESS, SCOTT T · 2021 to 2024
$2.4M
Sulfur Based Stem Cell Therapeutics in Necrotizing EnterocolitisR01DK133418 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI TROY A MARKEL · 2023 to 2026
$1.9M
NICHD NIH HHS R01 HD105301NIDDK NIH HHS R01 DK133418
6 · The paper itself

Abstract

backgroundHydrogen sulfide (H

methodsNecrotizing enterocolitis was induced in 5-day old wild type (WT) and eNOS

resultsIn WT mice, the administration of GYY4137 significantly improved clinical sickness scores, attenuated intestinal and lung injury, and improved mesenteric perfusion compared to vehicle (p < 0.05). In eNOS

conclusionsGYY4137 administration improves clinical outcomes, attenuates intestinal and lung injury, and improves perfusion in a murine model of necrotizing enterocolitis. The beneficial effects of GYY4137 are dependent on the Cys440 residue of eNOS.

Indexed as

Enterocolitis, NecrotizingHydrogen SulfideInfant, Newborn, DiseasesLung InjuryAnimalsDisease Models, AnimalHumansInfant, NewbornMiceMorpholinesNitric OxideNitric Oxide Synthase Type IIIOrganothiophosphorus CompoundsGYY 4137Hydrogen SulfideMorpholinesNitric OxideNitric Oxide Synthase Type IIIOrganothiophosphorus CompoundseNOSHydrogen sulfideNecrotizing enterocolitisNitric oxidePersulfidation

Identifiers

PMID37684170
PMCPMC10841167
OpenAlexW4386018533

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.