Evidence map›Paper›PMID 37684253›Full record

ArticleNature communications2023

CD44 connects autophagy decline and ageing in the vascular endothelium.

Lu Zhang, Peichang Yang, Jingxuan Chen, Zhiqiang Chen, Zhihui Liu, Gaoqing Feng, Fangfang Sha, Zirui Li, Zaoyi Xu, Yating Huang and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Age and the Diurnal Oscillatory Features of the Human Chronobiome.medRxiv : the preprint server for health sciences · 2026
    Article
  7. Article
  8. The Yin and Yang of copper in cardiovascular health and disease.Molecular and cellular biochemistry · 2026
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Review
  15. Article
  16. Autophagy: The convergence point of aging and cancer.Biochemistry and biophysics reports · 2025
    Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 1 institution in 1 country.

Lu Zhang *College of Bioengineering, Henan University of Technology, Lianhua Street, Zhengzhou, 450001, China. zhanglu@haut.edu.cn.ORCID http://orcid.org/0000-0003-4085-2980
Peichang Yang *College of Bioengineering, Henan University of Technology, Lianhua Street, Zhengzhou, 450001, China.
Jingxuan ChenCollege of Bioengineering, Henan University of Technology, Lianhua Street, Zhengzhou, 450001, China.
Zhiqiang ChenCollege of Bioengineering, Henan University of Technology, Lianhua Street, Zhengzhou, 450001, China.
Zhihui LiuCollege of Bioengineering, Henan University of Technology, Lianhua Street, Zhengzhou, 450001, China.
Gaoqing FengCollege of Bioengineering, Henan University of Technology, Lianhua Street, Zhengzhou, 450001, China.
Fangfang ShaCollege of Bioengineering, Henan University of Technology, Lianhua Street, Zhengzhou, 450001, China.
Zirui LiCollege of Bioengineering, Henan University of Technology, Lianhua Street, Zhengzhou, 450001, China.
Zaoyi XuCollege of Bioengineering, Henan University of Technology, Lianhua Street, Zhengzhou, 450001, China.
Yating HuangCollege of Bioengineering, Henan University of Technology, Lianhua Street, Zhengzhou, 450001, China.
Xiaotong ShiCollege of Bioengineering, Henan University of Technology, Lianhua Street, Zhengzhou, 450001, China.
Xuebiao LiCollege of Bioengineering, Henan University of Technology, Lianhua Street, Zhengzhou, 450001, China.
Jiatian CuiCollege of Bioengineering, Henan University of Technology, Lianhua Street, Zhengzhou, 450001, China.
Chenyi ZhangCollege of Bioengineering, Henan University of Technology, Lianhua Street, Zhengzhou, 450001, China.
Pei FanCollege of Bioengineering, Henan University of Technology, Lianhua Street, Zhengzhou, 450001, China.
Liuqing CuiCollege of Bioengineering, Henan University of Technology, Lianhua Street, Zhengzhou, 450001, China.
Yunpeng ShenCollege of Bioengineering, Henan University of Technology, Lianhua Street, Zhengzhou, 450001, China.
Guangzhou ZhouCollege of Bioengineering, Henan University of Technology, Lianhua Street, Zhengzhou, 450001, China.
Hongjuan JingCollege of Bioengineering, Henan University of Technology, Lianhua Street, Zhengzhou, 450001, China.
Shiwei MaCollege of Bioengineering, Henan University of Technology, Lianhua Street, Zhengzhou, 450001, China.
Henan University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The decline of endothelial autophagy is closely related to vascular senescence and disease, although the molecular mechanisms connecting these outcomes in vascular endothelial cells (VECs) remain unclear. Here, we identify a crucial role for CD44, a multifunctional adhesion molecule, in controlling autophagy and ageing in VECs. The CD44 intercellular domain (CD44ICD) negatively regulates autophagy by reducing PIK3R4 and PIK3C3 levels and disrupting STAT3-dependent PtdIns3K complexes. CD44 and its homologue clec-31 are increased in ageing vascular endothelium and Caenorhabditis elegans, respectively, suggesting that an age-dependent increase in CD44 induces autophagy decline and ageing phenotypes. Accordingly, CD44 knockdown ameliorates age-associated phenotypes in VECs. The endothelium-specific CD44ICD knock-in mouse is shorter-lived, with VECs exhibiting obvious premature ageing characteristics associated with decreased basal autophagy. Autophagy activation suppresses the premature ageing of human and mouse VECs overexpressing CD44ICD, function conserved in the CD44 homologue clec-31 in C. elegans. Our work describes a mechanism coordinated by CD44 function bridging autophagy decline and ageing.

Indexed as

Aging, PrematureEndothelium, VascularAgingAnimalsAutophagyCaenorhabditis elegansEndothelial CellsHumansHyaluronan ReceptorsMiceCD44 protein, humanHyaluronan Receptors

Identifiers

PMID37684253
PMCPMC10491636
OpenAlexW4386544205

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.