Evidence mapPaperPMID 37685330Full record

ArticleDiagnostics (Basel, Switzerland)2023

Corneal Confocal Microscopy Predicts Cardiovascular and Cerebrovascular Events and Demonstrates Greater Peripheral Neuropathy in Patients with Type 1 Diabetes and Foot Ulcers.

Jonathan Z M Lim, Jamie Burgess, Cheong Ooi, Maryam Ferdousi, Shazli Azmi, Alise Kalteniece, Matthew Anson, Daniel J Cuthbertson, Ioannis N Petropoulos, Rayaz A Malik and 2 more

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Is the 10 g monofilament fit for purpose for diagnosing DPN?BMJ open diabetes research & care · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Jonathan Z M LimDepartment of Cardiovascular & Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L69 3BX, UK.ORCID 0000-0003-3682-8910
Jamie BurgessDepartment of Cardiovascular & Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L69 3BX, UK.ORCID 0000-0002-7165-6918
Cheong OoiDepartment of Cardiovascular & Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L69 3BX, UK.
Maryam FerdousiInstitute of Cardiovascular Sciences, Cardiac Centre, Faculty of Medical and Human Sciences, University of Manchester and NIHR/Wellcome Trust Clinical Research Facility, Manchester M13 9WL, UK.
Shazli AzmiDiabetes, Endocrinology, and Metabolism Centre, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Manchester M13 9WL, UK.
Alise KaltenieceInstitute of Cardiovascular Sciences, Cardiac Centre, Faculty of Medical and Human Sciences, University of Manchester and NIHR/Wellcome Trust Clinical Research Facility, Manchester M13 9WL, UK.
Matthew AnsonDepartment of Cardiovascular & Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L69 3BX, UK.
Daniel J CuthbertsonDepartment of Cardiovascular & Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L69 3BX, UK.ORCID 0000-0002-6128-0822
Ioannis N PetropoulosDepartment of Medicine, Weill Cornell Medicine-Qatar, Doha P.O. Box 24144, Qatar.
Rayaz A MalikDepartment of Medicine, Weill Cornell Medicine-Qatar, Doha P.O. Box 24144, Qatar.ORCID 0000-0002-7188-8903
John P H WildingDepartment of Cardiovascular & Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L69 3BX, UK.
Uazman AlamDepartment of Cardiovascular & Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool L69 3BX, UK.ORCID 0000-0002-3190-1122
University of Liverpool · GBNIHR Wellcome Trust Southampton Clinical Research Facility · GBWeill Cornell Medical College in Qatar · QAManchester Royal Infirmary · GB

Funding

University of Liverpool UoL001379
6 · The paper itself

Abstract

objectiveIn this study, we evaluate small and large nerve fibre pathology in relation to diabetic foot ulceration (DFU) and incident cardiovascular and cerebrovascular events in type 1 diabetes (T1D).

methodsA prospective observational study was conducted on people with T1D without diabetic peripheral neuropathy (DPN) (

resultsCorneal nerve fibre length (CNFL), fibre density (CNFD) and branch density (CNBD) were lower in T1D-DPN and T1D-DFU vs. T1D (all

conclusionsOur study provides threshold values for corneal nerve fibre metrics for neuropathic foot at risk of DFU and further demonstrates that lower CNFD predicts incident cardiovascular and cerebrovascular events in T1D.

Indexed as

cardiovascular diseasecomplications of diabetescorneal confocal microscopydiabetic foot ulcerdiabetic peripheral neuropathytype 1 diabetes mellitus

Identifiers

PMID37685330
PMCPMC10486928
OpenAlexW4386255877

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.