Evidence map›Paper›PMID 37686002›Full record

ArticleInternational journal of molecular sciences2023

Underfeeding Alters Brain Tissue Synthesis Rate in a Rat Brain Injury Model.

Casey C Curl, Robert G Leija, Jose A Arevalo, Adam D Osmond, Justin J Duong, Daniela Kaufer, Michael A Horning, George A Brooks

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Altered glucose kinetics occurs with aging: a new outlook on metabolic flexibility.American journal of physiology. Endocrinology and metabolism · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Casey C CurlDepartment of Integrative Biology, University of California at Berkeley, Berkeley, CA 94720-3140, USA.ORCID 0000-0001-5772-7604
Robert G LeijaDepartment of Integrative Biology, University of California at Berkeley, Berkeley, CA 94720-3140, USA.ORCID 0000-0002-7862-293X
Jose A ArevaloDepartment of Integrative Biology, University of California at Berkeley, Berkeley, CA 94720-3140, USA.ORCID 0000-0002-1120-4960
Adam D OsmondDepartment of Integrative Biology, University of California at Berkeley, Berkeley, CA 94720-3140, USA.
Justin J DuongDepartment of Integrative Biology, University of California at Berkeley, Berkeley, CA 94720-3140, USA.
Daniela KauferDepartment of Integrative Biology, University of California at Berkeley, Berkeley, CA 94720-3140, USA.
Michael A HorningDepartment of Integrative Biology, University of California at Berkeley, Berkeley, CA 94720-3140, USA.
George A BrooksDepartment of Integrative Biology, University of California at Berkeley, Berkeley, CA 94720-3140, USA.ORCID 0000-0002-1389-1629
University of California, Berkeley · US

Funding

Aging Mitochondrial Fragmentation and Metabolic InflexibilityR01AG059715 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI BROOKS, GEORGE AUSTIN · 2018 to 2022
$3.0M
NIA NIH HHS R01 AG059715
6 · The paper itself

Abstract

Brain injuries (BI) are highly disruptive, often having long lasting effects. Inadequate standard of care (SOC) energy support in the hospital leads to dietary energy deficiencies in BI patients. However, it is unclear how underfeeding (UF) affects protein synthesis post-BI. Therefore, in a rat model, we addressed the issue of UF on the protein fractional synthesis rate (fSR) post-BI. Compared to ad libitum (AL)-fed animals, we found that UF decreased protein synthesis in hind-limb skeletal muscle and cortical mitochondrial and structural proteins (

Indexed as

Brain InjuriesMalnutritionAnimalsBrainCerebellumCerebral CortexCytosolRatsbrain injurygluconeogenesisrecoverystandard of care

Identifiers

PMID37686002
PMCPMC10487942
OpenAlexW4386161805

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.