Evidence map›Paper›PMID 37686200›Full record

ArticleInternational journal of molecular sciences2023

Detection and Monitoring of Tumor-Derived Mutations in Circulating Tumor DNA Using the UltraSEEK Lung Panel on the MassARRAY System in Metastatic Non-Small Cell Lung Cancer Patients.

Paul van der Leest, Melanie Janning, Naomi Rifaela, Maria L Aguirre Azpurua, Jolanthe Kropidlowski, Sonja Loges, Nicolas Lozano, Alexander Sartori, Darryl Irwin, Pierre-Jean Lamy and 6 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in International journal of molecular sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Diagnostic accuracy of next-generation sequencing (NGS) for identifying actionable mutations in advanced non-small cell lung cancer: Systematic Review and Meta-Analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Pooled it
  2. Pooled it
  3. Article
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 3 countries.

Paul van der LeestDepartment of Pathology (EA10), University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.ORCID 0000-0001-8527-4956
Melanie JanningGerman Cancer Research Center (DKFZ)-Hector Cancer Institute, University Medical Center Mannheim, 68167 Mannheim, Germany.ORCID 0000-0002-6632-8506
Naomi RifaelaDepartment of Pathology (EA10), University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Maria L Aguirre AzpuruaDepartment of Pathology (EA10), University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Jolanthe KropidlowskiDepartment of Tumor Biology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Sonja LogesDivision of Personalized Medical Oncology (A420), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Nicolas LozanoInstitut d'Analyse Génomique Imagenome, Labosud, 34070 Montpellier, France.ORCID 0000-0003-4739-285X
Alexander SartoriAgena Bioscience GmbH, 22761 Hamburg, Germany.
Darryl IrwinAgena Bioscience, Brisbane 4006, Australia.ORCID 0000-0003-4842-6708
Pierre-Jean LamyInstitut d'Analyse Génomique Imagenome, Labosud, 34070 Montpellier, France.ORCID 0000-0002-5750-159X
T Jeroen N HiltermannDepartment of Pulmonary Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.ORCID 0000-0002-0665-2160
Harry J M GroenDepartment of Pulmonary Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.ORCID 0000-0002-2978-5265
Klaus PantelDepartment of Tumor Biology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.ORCID 0000-0001-5736-2772
Léon C van KempenDepartment of Pathology (EA10), University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.ORCID 0000-0003-0646-0705
Harriet WikmanDepartment of Tumor Biology, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.ORCID 0000-0001-6862-0888
Ed SchuuringDepartment of Pathology (EA10), University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.ORCID 0000-0003-3655-143X
University Medical Center Groningen · NLUniversität Hamburg · DEClinique du Millénaire · FR

Funding

Agena Bioscience N/ABio-Rad N/A
6 · The paper itself

Abstract

Analysis of circulating tumor DNA (ctDNA) is a potential minimally invasive molecular tool to guide treatment decision-making and disease monitoring. A suitable diagnostic-grade platform is required for the detection of tumor-specific mutations with high sensitivity in the circulating cell-free DNA (ccfDNA) of cancer patients. In this multicenter study, the ccfDNA of 72 patients treated for advanced-stage non-small cell lung cancer (NSCLC) was evaluated using the UltraSEEK

Indexed as

Carcinoma, Non-Small-Cell LungCell-Free Nucleic AcidsCirculating Tumor DNALung NeoplasmsDisease ProgressionHumansLungMutationCell-Free Nucleic AcidsCirculating Tumor DNAcirculating tumor DNAliquid biopsymetastatic non-small cell lung cancerprogressive diseaseresistance mutations

Identifiers

PMID37686200
PMCPMC10487510
OpenAlexW4386251112

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.