ArticleInternational journal of obesity (2005)2023
Kidney damage predictors in children with metabolically healthy and metabolically unhealthy obesity phenotype.
Article in International journal of obesity (2005), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Late-adolescent weight categories and early kidney disease in young adulthood: a nationwide study of Arab and Jewish Israelis.Pediatric nephrology (Berlin, Germany) · 2026Article
- Pediatric hyperuricemia: genetic basis, metabolic mechanisms, and clinical implications.Frontiers in endocrinology · 2026Review
- Insights into renal damage in hyperuricemia: Focus on renal protection (Review).Molecular medicine reports · 2025Review
- Beyond Cardiometabolic: Health Disorders Risk in Metabolically Healthy Obese Children - A Systematic Review and Meta-Analysis of 19,119 Children.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Review
- Association of weight-adjusted waist index and Albuminuria in children and adolescents: A national population-based study.PloS one · 2025Article
- Kidney Damage in Pediatric Obesity: Insights from an Emerging Perspective.Journal of clinical medicine · 2024Article
- Effectiveness of Smartphone App for the Treatment of Pediatric Obesity: A Randomized Controlled Trial.Children (Basel, Switzerland) · 2024Article
- Kidney function evaluation in children and adolescents with obesity: a not-negligible need.European journal of pediatrics · 2024Review
- Interplay between metabolic dysfunction-associated fatty liver disease and renal function: An intriguing pediatric perspective.World journal of gastroenterology · 2024Article
- Sex-Related Differences in Cardiovascular Risk in Adolescents with Overweight or Obesity.Reviews in cardiovascular medicine · 2024Article
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Authors and funding
9 authors at 1 institution in 1 country.
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Abstract
backgroundObesity and kidney damage have been closely linked in adults, but little is still known in childhood.
objectiveTo identify predictors of kidney damage in children with metabolically healthy (MHO) and metabolically unhealthy (MUO) obesity phenotypes.
methodsWe retrospectively examined 396 children with obesity (mean age 10.72 ± 2.71 years, body mass index-standard deviation score, BMI-SDS, 2.23 ± 0.57) stratified according to metabolic phenotypes. Kidney damage was defined as the presence of reduced estimated glomerular filtration rate (eGFR < 90 mL/min/1.73m2) and/or albuminuria (≥ 30 mg/g urinary creatinine).
resultsKidney damage was found in 20.9% of the study population. Children with kidney damage had higher BMI-SDS, homeostasis model assessment of insulin resistance (HOMA-IR), and inflammation markers levels and increased prevalence of non-alcoholic fatty liver disease (NAFLD) than those without kidney damage (all p < 0.005). MUO and MHO subjects had respectively an odds ratio (OR) to show kidney damage of of 1.92 (95%CI:1.22-3.01; p = 0.005) and 1.05 (95%CI:1.00-1.09; p = 0.028) after adjustments. Moreover, we found that only HOMA-IR was closely associated to kidney damage in MUO group (OR = 2.07;95%CI:1.20-3.57; p = 0.007), while HOMA-IR (OR = 1.15;95%CI:1.02-1.29; p = 0.011) and uric acid (OR = 1.15;95% CI:1.02-1.30; p = 0.010) were the only significant risk factors for kidney damage in MHO group.
conclusionAn increased risk of kidney damage has been observed in children with obesity and in particular in those with MUO phenotype. As their role on kidney function, HOMA-IR should be monitored in MUO children and both HOMA-IR and uric acid in MHO children.
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