ArticlebioRxiv : the preprint server for biology2023
Unravelling human hematopoietic progenitor cell diversity through association with intrinsic regulatory factors.
Patricia Favaro, David R Glass, Luciene Borges, Reema Baskar, Warren Reynolds, Daniel Ho, Trevor Bruce, Dmitry Tebaykin, Vanessa M Scanlon, Ilya Shestopalov and 1 more
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors at 6 institutions in 4 countries.
Patricia FavaroDepartment of Pathology, Stanford University.
David R GlassDepartment of Pathology, Stanford University.
Luciene BorgesDepartment of Pathology, Stanford University.
Reema BaskarDepartment of Pathology, Stanford University.
Warren ReynoldsDepartment of Pathology, Stanford University.
Daniel HoDepartment of Pathology, Stanford University.
Trevor BruceDepartment of Pathology, Stanford University.
Dmitry TebaykinDepartment of Pathology, Stanford University.
Vanessa M ScanlonDepartment of Laboratory Medicine, Yale School of Medicine.
Ilya Shestopalovbluebird bio, inc.
Sean C BendallDepartment of Pathology, Stanford University.
Stanford University · USBluebird Bio (United States) · USBoehringer Ingelheim (France) · FRCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZAGenome Institute of Singapore · SGUniversity of Connecticut · US
Funding
Stanford Alzheimer's Disease Research CenterAdmin Supp: Developing iPSC models for AD and PDP30AG066515 · NIA · STANFORD UNIVERSITY · PI ELIZABETH MORMINO · 2020 to 2026
$29.0MStanford Cancer Immune Monitoring and Analysis Center (CIMAC)U24CA224309 · NCI · STANFORD UNIVERSITY · PI Sean Curtis Bendall, Holden T. Maecker · 2017 to 2026
$19.9MProject 4: Novel reagent development to enable molecular characterizationU19AG065156 · NIA · UNIVERSITY OF WASHINGTON · PI TIAN, LU · 2020 to 2024
$15.9MThe Bone Marrow Multi-modal Imaging CoreU54HL165445 · NHLBI · STANFORD UNIVERSITY · PI ANGELO, ROBERT MICHAEL, BENDALL, SEAN CURTIS · 2022 to 2025
$5.9MMIRIAD - Multiplexed Imaging of Resilience In Alzheimers DiseaseR01AG057915 · NIA · STANFORD UNIVERSITY · PI ANGELO, ROBERT MICHAEL, BENDALL, SEAN CURTIS · 2017 to 2021
$4.5MThe Phenotypic Landscape of Cognitive Decline as Revealed by Next-Generation Multiplexed Ion Beam ImagingR01AG056287 · NIA · STANFORD UNIVERSITY · PI ANGELO, ROBERT MICHAEL, BENDALL, SEAN CURTIS · 2017 to 2021
$2.6MOrigins of human blood lineages in regenerative medicineDP2EB024246 · NIBIB · STANFORD UNIVERSITY · PI BENDALL, SEAN CURTIS · 2016 to 2016
$2.4MUncoupling Age- Versus Cognitive-Related Cellular Senescence in Alzheimer's DiseaseR01AG068279 · NIA · STANFORD UNIVERSITY · PI BENDALL, SEAN CURTIS · 2020 to 2024
$1.9MThe Role of Intrinsic and Extrinsic Factors in Megakaryocytic-Erythroid Progenitor Lineage CommitmentK01DK120798 · NIDDK · YALE UNIVERSITY · PI SCANLON, VANESSA M. · 2019 to 2023
$931kNCI NIH HHS U24 CA224309NHLBI NIH HHS U54 HL165445NIA NIH HHS P30 AG066515NIA NIH HHS R01 AG056287NIA NIH HHS R01 AG057915NIA NIH HHS R01 AG068279NIA NIH HHS U19 AG065156NIBIB NIH HHS DP2 EB024246NIDDK NIH HHS K01 DK120798
6 · The paper itselfAbstract
Hematopoietic stem and progenitor cell (HSPC) transplantation is an essential therapy for hematological conditions, but finer definitions of human HSPC subsets with associated function could enable better tuning of grafts and more routine, lower-risk application. To deeply phenotype HSPCs, following a screen of 328 antigens, we quantified 41 surface proteins and functional regulators on millions of CD34+ and CD34- cells, spanning four primary human hematopoietic tissues: bone marrow, mobilized peripheral blood, cord blood, and fetal liver. We propose more granular definitions of HSPC subsets and provide new, detailed differentiation trajectories of erythroid and myeloid lineages. These aspects of our revised human hematopoietic model were validated with corresponding epigenetic analysis and
Indexed as
ATAC-seqbone marrowcord blooderythrocyte/megakaryocyte lineagefetal liverhematopoietic stem and progenitor cellhuman hematopoiesismass cytometrymobilized peripheral bloodmolecular regulatormyeloid lineagepseudotimesingle-celltrajectory analysistranscription factor
Identifiers
PMID37693547
PMCPMC10491219
OpenAlexW4386331284
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390