Evidence map›Paper›PMID 37694147›Full record

ArticleiScience2023

WNK1 is required during male pachynema to sustain fertility.

Ru-Pin Alicia Chi, Xiaojiang Xu, Jian-Liang Li, Xin Xu, Guang Hu, Paula Brown, Cynthia Willson, Oleksandr Kirsanov, Christopher Geyer, Chou-Long Huang and 2 more

Open access · goldAbstract read
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Genomic Patterns are Associated with Different Sequelae of Patients with Long-Term COVID-19.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Ru-Pin Alicia ChiReproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, Durham, NC 27709, USA.
Xiaojiang XuIntegrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, Durham, NC 27709, USA.
Jian-Liang LiIntegrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, Durham, NC 27709, USA.
Xin XuEpigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Durham, NC 27709, USA.
Guang HuEpigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, Durham, NC 27709, USA.
Paula BrownReproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, Durham, NC 27709, USA.
Cynthia WillsonIntegrated Laboratory Systems LLC, Research Triangle Park, NC 27709, USA.
Oleksandr KirsanovDepartment of Anatomy & Cell Biology at the Brody School of Medicine at East Carolina University, Greenville, NC 27834, USA.
Christopher GeyerDepartment of Anatomy & Cell Biology at the Brody School of Medicine at East Carolina University, Greenville, NC 27834, USA.
Chou-Long HuangDepartment of Internal Medicine, University of Iowa Carver College of Medicine, Iowa, IA 52242, USA.
Marcos MorganReproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, Durham, NC 27709, USA.
Francesco DeMayoReproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, Durham, NC 27709, USA.
East Carolina University · US

Funding

Environmental Signaling in Reproduction and PregnancyZIAES103311 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI DEMAYO, FRANCESCO · 2016 to 2025
$30.5M
Role of RNA modifications in spermatogenesis.ZIAES103339 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI MORGAN, MARCOS · 2019 to 2025
$10.8M
University of Iowa Hawkeye Intellectual and Developmental Disabilities Research Center (Hawk-IDDRC)P50HD103556 · NICHD · UNIVERSITY OF IOWA · PI EDWIN TED G. ABEL, Lane Strathearn · 2021 to 2026
$8.5M
WNK kinase cascade in health and diseaseR01DK111542 · NIDDK · UNIVERSITY OF IOWA · PI Chou-Long Huang · 2017 to 2026
$3.6M
Regulation of Renal Calcium Transport in Health and DiseaseR01DK109887 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI HUANG, CHOU-LONG · 2016 to 2020
$1.8M
The role of retinoid exposure in specification of the foundational SSC poolR01HD090083 · NICHD · EAST CAROLINA UNIVERSITY · PI GEYER, CHRISTOPHER BENNETT · 2017 to 2021
$1.4M
Challenging the role of retinoic acid in meiotic initiationR21HD105963 · NICHD · EAST CAROLINA UNIVERSITY · PI GEYER, CHRISTOPHER BENNETT · 2022 to 2023
$424k
Intramural NIH HHS ZIA ES103311Intramural NIH HHS ZIA ES103339NICHD NIH HHS P50 HD103556NICHD NIH HHS R01 HD090083NICHD NIH HHS R21 HD105963NIDDK NIH HHS R01 DK109887NIDDK NIH HHS R01 DK111542
6 · The paper itself

Abstract

WNK1 is an important regulator in many physiological functions, yet its role in male reproduction is unexplored. In the male germline, WNK1 is upregulated in preleptotene spermatocytes indicating possible function(s) in spermatogenic meiosis. Indeed, deletion of

Indexed as

Cell biologyMolecular biologyOmicsPhysiologyTranscriptomics

Identifiers

PMID37694147
PMCPMC10485039
OpenAlexW4385782189

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.