Evidence map›Paper›PMID 37694182›Full record

ReviewTherapeutic advances in musculoskeletal disease2023

Application of clinical and molecular profiling data to improve patient outcomes in psoriatic arthritis.

Oliver FitzGerald, Frank Behrens, Anne Barton, Heidi Bertheussen, Bruno Boutouyrie-Dumont, Laura Coates, Owen Davies, Maarten de Wit, Filippo Fagni, Carl S Goodyear and 21 more

Abstract readReview
In one paragraph

Review in Therapeutic advances in musculoskeletal disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Oliver FitzGeraldSchool of Medicine, UCD Conway Institute for Biomolecular Research, University College Dublin, Ireland.ORCID https://orcid.org/0000-0002-6607-6070
Frank BehrensTranslational Rheumatology, Immunology - Inflammation Medicine, University Hospital Goethe-University, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP and Fraunhofer Cluster of Excellence Immune Mediated Diseases, Frankfurt, Germany.
Anne BartonCentre for Musculoskeletal Research, the University of Manchester, Manchester, UK.
Heidi BertheussenGRAPPA Patient Research Partner, Norway.
Bruno Boutouyrie-DumontNovartis Institutes for BioMedical Research, Basel, Switzerland.
Laura CoatesNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-4756-663X
Owen DaviesUCB Pharma, Slough, UK.
Maarten de WitGRAPPA Patient Research Partner, Zaltbommel, the Netherlands.ORCID https://orcid.org/0000-0002-8428-6354
Filippo FagniDepartment of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.
Carl S GoodyearSchool of Infection & Immunity, College of Medical, Veterinar & Life Sciences, University of Glasgow, Glasgow, UK.
Robert GurkePharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP and Fraunhofer Cluster of Excellence Immune Mediated Diseases, Frankfurt, Germany.
Lisa HahnefeldPharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP and Fraunhofer Cluster of Excellence Immune Mediated Diseases, Frankfurt, Germany.ORCID https://orcid.org/0000-0002-0382-5695
Christine HuppertzNovartis Institutes for BioMedical Research, Basel, Switzerland.
Vassilios IoannidisVital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Mark IbbersonVital-IT Group, SIB Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Arnon KatzGRAPPA Patient Research Partner, Israel.
Maximilian KlippsteinTranslational Rheumatology, Immunology - Inflammation Medicine, University Hospital Goethe-University, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP and Fraunhofer Cluster of Excellence Immune Mediated Diseases, Frankfurt, Germany.
Michaela KoehmTranslational Rheumatology, Immunology - Inflammation Medicine, University Hospital Goethe-University, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP and Fraunhofer Cluster of Excellence Immune Mediated Diseases, Frankfurt, Germany.
Shimon KorishBristol Myers Squibb, Princeton, NJ, USA.
Sina MackayFraunhofer Institute for Intelligent Analysis and Information Systems IAIS, Sankt Augustin and Fraunhofer Cluster of Excellence Immune Mediated Diseases, Frankfurt, Germany.
David A MartinPfizer Immunology & Inflammation Research Unit, Cambridge, MA, USA.
Denis O'SullivanGRAPPA Patient Research Partner, Ireland.
Khadijah PatelCentre for Musculoskeletal Research, the University of Manchester, Manchester, UK.
Stefan RuepingFraunhofer Institute for Intelligent Analysis and Information Systems IAIS, Sankt Augustin and Fraunhofer Cluster of Excellence Immune Mediated Diseases, Frankfurt, Germany.
Georg SchettDepartment of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.
Klaus ScholichPharmazentrum frankfurt/ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP and Fraunhofer Cluster of Excellence Immune Mediated Diseases, Frankfurt, Germany.
Jochen M SchwenkAffinity Proteomics, Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, Solna, Sweden.ORCID https://orcid.org/0000-0001-8141-8449
Stefan SiebertSchool of Infection & Immunity, College of Medical, Veterinar & Life Sciences, University of Glasgow, Glasgow, UK.ORCID https://orcid.org/0000-0002-1802-7311
David SimonDepartment of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany.
Arani VivekananthamNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Stephen R PenningtonSchool of Medicine, UCD Conway Institute for Biomolecular Research, University College Dublin, Ireland.ORCID https://orcid.org/0000-0001-7529-1015

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Achieving a good outcome for a person with Psoriatic Arthritis (PsA) is made difficult by late diagnosis, heterogenous clinical disease expression and in many cases, failure to adequately suppress inflammatory disease features. Single-centre studies have certainly contributed to our understanding of disease pathogenesis, but to adequately address the major areas of unmet need, multi-partner, collaborative research programmes are now required. HIPPOCRATES is a 5-year, Innovative Medicines Initiative (IMI) programme which includes 17 European academic centres experienced in PsA research, 5 pharmaceutical industry partners, 3 small-/medium-sized industry partners and 2 patient-representative organizations. In this review, the ambitious programme of work to be undertaken by HIPPOCRATES is outlined and common approaches and challenges are identified. It is expected that, when completed, the results will ultimately allow for changes in the approaches to diagnosing, managing and treating PsA allowing for better short-term and long-term outcomes.

Indexed as

diagnosisHIPPOCRATESIMImulti-omicspatient outcomespsoriasispsoriatic arthritis

Identifiers

PMID37694182
PMCPMC10492462

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.