Evidence map›Paper›PMID 37695291›Full record

ArticlePsycho-oncology2023

Greater fertility distress and avoidance relate to poorer decision making about family building after cancer among adolescent and young adult female survivors.

Catherine Benedict, Julia Stal, Ali Davis, Anna Zeidman, Devon Pons, Lidia Schapira, Michael Diefenbach, Jennifer S Ford

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psycho-oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06894810 (A Double Blind Randomised Controlled Trial of a Paediatric Fertility Preservation Decision Aid in Parents and Adolescents and Young Adults), which is not on this map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06894810 narecruitingnot on this mapstarted 2025, after this paper: background citation

A Double Blind Randomised Controlled Trial of a Paediatric Fertility Preservation Decision Aid in Parents and Adolescents and Young Adults (CAYA) Cancer Survivors

TypeinterventionalSponsorMurdoch Childrens Research InstituteRan2025 to 2027Enrolled358ConditionsUnmet Fertility Information NeedsArmsDecision-aid
3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. Review
  6. Desire for future children and interest in consultation with a fertility specialist among adolescent and young adult (AYA) cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  7. Counseling and use of surrogacy among cancer survivors (CUSACS).Journal of cancer survivorship : research and practice · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Perceived impact of a decision-aid and planning tool for family building after cancer for young adult female cancer survivors.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Catherine BenedictDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA.ORCID 0000-0001-9622-249X
Julia StalDepartment off Population and Public Health Sciences, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
Ali DavisDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Anna ZeidmanDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA.
Devon PonsUniversity of San Francisco, San Francisco, California, USA.
Lidia SchapiraStanford Cancer Institute, Stanford, California, USA.
Michael DiefenbachDonald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, New York, USA.
Jennifer S FordHunter College and The Graduate Center, City University of New York (CUNY), New York, New York, USA.

Funding

Family-building After Cancer: Preferences, Decisions, and Planning for Young Female SurvivorsK07CA229186 · NCI · STANFORD UNIVERSITY · PI BENEDICT, CATHERINE · 2018 to 2023
$696k
Developing a Decision Aid for Adolescent and Young Adult Female Cancer Survivors Considering Future Family-Building after TreatmentR03CA212924 · NCI · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI DIEFENBACH, MICHAEL A · 2017 to 2018
$165k
NCI NIH HHS K07 CA229186NCI NIH HHS R03 CA212924
6 · The paper itself

Abstract

backgroundMany adolescent and young adult female (AYA-F) cancer survivors face decisions about family building using reproductive medicine or adoption to achieve parenthood. This study evaluated associations among reproductive distress, avoidance, and family-building decision making and identified sociodemographic and clinical characteristics related to high distress and avoidance.

methodsA cross-sectional survey assessed AYA-F survivors' oncofertility experiences. Measures included an investigator-designed Unmet Information Needs scale, Reproductive Concerns After Cancer Scale, Impact of Events Scale-Avoidance subscale, Decision Self-Efficacy scale, and Decision Conflict Scale. Two linear regression models evaluated correlates of decision self-efficacy and decisional conflict about family building after cancer. Bivariate analyses evaluated correlates of avoidance using Pearson's correlation, t-test, and ANOVA.

resultsAYA-Fs (N = 111) averaged 31-years-old (SD = 5.49) and 3 years post-treatment (range: 1-23 years); 90% were nulliparous. Most common diagnoses were leukemia (24%) and breast cancer (22%). Average decisional conflict was 52.12 (SD = 23.87, range: 0-100); 74% of the sample reported DCS scores within the clinically significant range. Higher levels of reproductive distress (B = -0.23, p = 0.04) and avoidance (B = -0.24, p = 0.02) related to lower decision self-efficacy. Younger age (B = -0.18, p = 0.03), greater unmet information needs (B = 0.33, p < 0.001), and higher levels of reproductive distress (B = 0.34, p = 0.001) related to worse decisional conflict. Predictors of distress and avoidance were identified.

conclusionsAfter cancer treatment, high fertility distress and avoidant coping were associated with poorer quality decision making about family building after cancer. Fertility counseling post-treatment should support self-efficacy and constructive coping skills to counteract high distress, maladaptive coping, and facilitate values-based decision making.

Indexed as

Breast NeoplasmsFertility PreservationNeoplasmsAdolescentAdultCross-Sectional StudiesDecision MakingFemaleFertilityHumansSurvivorsYoung Adultadolescent and young adult cancerdecision makingfertilityinfertilityoncofertilityreproductive distress

Identifiers

PMID37695291
PMCPMC10591918

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.