Evidence map›Paper›PMID 37696384›Full record

ArticleArchives of biochemistry and biophysics2023

Investigating the catalytic efficiency of C22-Fatty acids with LOX human isozymes and the platelet response of the C22-oxylipin products.

Michelle Tran, Livia Stanger, Srihari Narendra, Michael Holinstat, Theodore R Holman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of biochemistry and biophysics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Michelle TranDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Livia StangerDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Srihari NarendraDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Michael HolinstatDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA.
Theodore R HolmanDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA 95064, USA. Electronic address: holman@ucsc.edu.
University of California, Santa Cruz · USUniversity of Michigan · US

Funding

Interdepartmental Training in Pharmacological SciencesT32GM140223 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lori L. Isom · 2021 to 2026
$3.8M
12-HETrE regulation of blood coagulation, hemostasis, and thrombosisR35GM131835 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLINSTAT, MICHAEL ALLAN · 2019 to 2023
$2.3M
NIGMS NIH HHS R35 GM131835NIGMS NIH HHS T32 GM140223
6 · The paper itself

Abstract

Polyunsaturated fatty acids (PUFAs) have been extensively studied for their health benefits because they can be oxidized by lipoxygenases to form bioactive oxylipins. In this study, we investigated the impact of double bond placement on the kinetic properties and product profiles of human platelet 12-lipoxygenase (h12-LOX), human reticulocyte 15-lipoxygenase-1 (h15-LOX-1), and human endothelial 15-lipoxygenase-2 (h15-LOX-2) by using 22-carbon (C22) fatty acid substrates with differing double bond content. With respect to k

Indexed as

Fatty AcidsOxylipinsArachidonate 15-LipoxygenaseCollagenHumansIsoenzymesScavenger Receptors, Class EArachidonate 15-LipoxygenaseCollagenFatty AcidsIsoenzymesOxylipinsScavenger Receptors, Class E

Identifiers

PMID37696384
PMCPMC10821779
OpenAlexW4386570225

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.