Evidence map›Paper›PMID 37698776›Full record

SynthesisInflammopharmacology2023

The role of probiotic supplementation in inflammatory biomarkers in adults: an umbrella meta-analysis of randomized controlled trials.

Amir Hossein Faghfouri, Ladan Gol Mohammad Pour Afrakoti, Zeynab Kavyani, Zahra Sadeghi Nogourani, Vali Musazadeh, Mahdi Jafarlou, Parvin Dehghan

Abstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Inflammopharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 12 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amir Hossein Faghfouri *Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran.
Ladan Gol Mohammad Pour Afrakoti *Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Zeynab KavyaniStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Zahra Sadeghi NogouraniSchool of Medicine, Najafabad Branch, Islamic Azad University, Najafabad, Isfahan, Iran.
Vali MusazadehStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. Mosazadeh.vali05@gmail.com.ORCID http://orcid.org/0000-0002-4978-9474
Mahdi JafarlouFaculty of Medicine and Health Science, UPM, 43400, Serdang, Malaysia.
Parvin DehghanDepartment of Clinical Nutrition, School of Nutrition and Food Sciences, Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Dehghannut@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDespite the increasing evidence for probiotics' anti-inflammatory effects, the results of meta-analyses remain inconsistent. The present umbrella meta-analysis aimed to investigate the effects of probiotic supplementation on inflammatory biomarkers.

methodsWe performed a wide-ranging systematic search in several databases, including PubMed, Web of Science, Scopus, EMBASE, and Google Scholar up to April 2023. The overall effect sizes were calculated using effect size (ES) values and their corresponding confidence intervals (CI).

resultsOut of a total of 580 related articles, 39 studies were qualified for inclusion in the analysis. The results of the analysis revealed a significant reduction of C-reactive protein (CRP) (ES = -1.02; 95% CI: -1.23, -0.80, p < 0.001; I

conclusionProbiotic supplementation significantly reduced serum concentrations of TNF-a, CRP, and IL-6. Thus, probiotic supplementation can be considered adjuvant therapy to alleviate inflammation in various inflammatory conditions.

Indexed as

Interleukin-6ProbioticsAdultBiomarkersC-Reactive ProteinHumansRandomized Controlled Trials as TopicBiomarkersC-Reactive ProteinInterleukin-6CytokinesInflammationProbioticsUmbrella meta-analysis

Identifiers

PMID37698776

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.