ArticleJournal of orthopaedic surgery and research2023
Causal effect of body mass index and physical activity on the risk of joint sports injuries: Mendelian randomization analysis in the European population.
Article in Journal of orthopaedic surgery and research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Sex-Specific Patterns of Force Plate-Derived Predictors for Vertical Jump Performance and Algorithmic Musculoskeletal Injury Risk in College Athletes.Sports (Basel, Switzerland) · 2026Article
- Impact of overweight on spatiotemporal gait parameters and lower-limb biomechanics in functional ankle instability.Frontiers in physiology · 2026Article
- Associations between flexibility, stretching habits, and spine injuries in professional golfers: a nationwide, cross-sectional study.Journal of orthopaedic surgery and research · 2025Article
- Bidirectional causal relationship between obesity and osteoarthritis: Insights from a two-sample Mendelian randomization study.Osteoarthritis and cartilage open · 2025Article
- Padel related injuries: prevalence and characteristics in chilean amateur players - a cross sectional analytic study.BMC sports science, medicine & rehabilitation · 2025Article
- Characteristics of spinal injury in professional golfers in South Korea: a nationwide cross-sectional study.BMJ open · 2025Article
- Morphology of male world cup and elite bouldering athletes.Frontiers in sports and active living · 2025Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObservational studies can suggest potential associations between variables but cannot establish a causal effect on their own. This study explored the causal associations between body mass index (BMI), physical activity (PA), and joint sports injuries.
methodsWe conducted two-sample Mendelian randomization (MR) using publicly accessed genome-wide association studies (GWAS) datasets to investigate the causal effects of BMI and PA on joint sports injury risk. The inverse-variance weighted method was believed to be the primary MR analysis. Subsequently, sensitivity, pleiotropy, and heterogeneity analyses were employed to estimate the reliability of the results of the current research.
resultsGenetically predicted increased BMI was causally related to the higher sports injury risk of the ankle-foot (OR 1.23, 95% CI 1.09-1.37, p = 4.20E-04), knee (OR 1.32, 95% CI 1.21-1.43, p = 1.57E-11), and shoulder (OR 1.23, 95% CI 1.08-1.40, p = 1.28E-03). Further, the mentioned effects were validated using another set of GWAS data on BMI. Similar causal linkages were exhibited between increased BMI and the growing risk of sports injuries of the ankle-foot (OR 1.34, 95% CI 1.13-1.60, p = 9.51E-04), knee (OR 1.26, 95% CI 1.09-1.45, p = 1.63E-03), and shoulder (OR 1.35, 95% CI 1.09-1.67, p = 5.66E-03). Additionally, accelerometer-based PA measurement (overall average acceleration) (AccAve) was negatively related to sports injuries of the ankle-foot (OR 0.93, 95% CI 0.87-0.99, p = 0.046) and lumbar spine (OR 0.68, 95% CI 0.51-0.92, p = 0.012). Furthermore, we verified that the effect of AccAve on the risk of injury at the ankle-foot still had statistical significance after adjusting BMI. Results were verified as reliable under all sensitive analyses.
conclusionsThis research determined that a higher BMI could raise the sports injury risk of the ankle-foot, knee, and shoulder, while an overall average acceleration PA could reduce the injury risk of the ankle-foot and lumbar spine. These conclusions contribute to a greater knowledge of the roles of BMI and PA in the mechanism of joint sports injuries and offer several suggestions for patients and clinicians.
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