Evidence map›Paper›PMID 37703138›Full record

ArticleIEEE transactions on medical imaging2024

Time-Lagged Functional Ultrasound for Multi-Parametric Cerebral Hemodynamic Imaging.

Bingxue Liu, Yongchao Wang, Natalie Fomin-Thunemann, Martin Thunemann, Kivilcim Kilic, Anna Devor, Xiaojun Cheng, Jiyong Tan, John Jiang, David A Boas and 1 more

Open access · greenAbstract read
In one paragraph

Article in IEEE transactions on medical imaging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Bingxue Liu
Yongchao Wang
Natalie Fomin-Thunemann
Martin Thunemann
Kivilcim Kilic
Anna Devor
Xiaojun Cheng
Jiyong Tan
John Jiang
David A Boas
Jianbo Tang
Boston University · USSouthern University of Science and Technology · CN

Funding

Project 4U19NS123717 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI DEVOR, ANNA · 2021 to 2025
$13.4M
Neurophotonic Advances for Mechanistic Investigation of the Role of Capillary Dysfunction in Stroke RecoveryR01NS127156 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI David A Boas · 2022 to 2026
$3.3M
The impact of microvascular (dys)regulation on cerebral flow and oxygen heterogeneityR01NS108472 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI BOAS, DAVID A, SCHAFFER, CHRIS B · 2018 to 2022
$3.2M
Effects of intrinsic and drug-induced neuromodulation on functional brain imagingR01DA050159 · NIDA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI DEVOR, ANNA · 2020 to 2024
$1.9M
NIDA NIH HHS R01 DA050159NINDS NIH HHS R01 NS108472NINDS NIH HHS R01 NS127156NINDS NIH HHS U19 NS123717
6 · The paper itself

Abstract

We introduce an ultrasound speckle decorrelation-based time-lagged functional ultrasound technique (tl-fUS) for the quantification of the relative changes in cerebral blood flow speed (rCBF [Formula: see text]), cerebral blood volume (rCBV) and cerebral blood flow (rCBF) during functional stimulations. Numerical simulations, phantom validations, and in vivo mouse brain experiments were performed to test the capability of tl-fUS to parse out and quantify the ratio change of these hemodynamic parameters. The blood volume change was found to be more prominent in arterioles compared to venules and the peak blood flow changes were around 2.5 times the peak blood volume change during brain activation, agreeing with previous observations in the literature. The tl-fUS shows the ability of distinguishing the relative changes of rCBFspeed, rCBV, and rCBF, which can inform specific physiological interpretations of the fUS measurements.

Indexed as

Brain NeoplasmsHemodynamicsAnimalsBlood VolumeBrainCerebrovascular CirculationMagnetic Resonance ImagingMiceUltrasonography

Identifiers

PMID37703138
PMCPMC10947997
OpenAlexW4386702643

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.