Evidence map›Paper›PMID 37704386›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Why and How to Account for Sex and Gender in Brain and Behavioral Research.

Lise Eliot, Annaliese K Beery, Emily G Jacobs, Hannah F LeBlanc, Donna L Maney, Margaret M McCarthy

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Claims of sex-dependent effects in the behavioral and brain sciences are infrequently supported by valid statistical comparisons.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Review
  5. Gendering the Menstrual Cycle in Behavioral Neuroendocrinology.American journal of human biology : the official journal of the Human Biology Council · 2026
    Review
  6. Review
  7. Article
  8. Article
  9. The role of affective states in computational psychiatry.The international journal of neuropsychopharmacology · 2025
    Review
  10. Article
  11. "Precision Medicine" and the Failed Search for Binary Brain Sex Differences to Address Gender Behavioral Health Disparities.American journal of human biology : the official journal of the Human Biology Council · 2025
    Review
  12. Chronic Stress May Amplify Gender/Sex Differences in Amygdala Reactivity to Ambiguous Emotional Stimuli.Stress and health : journal of the International Society for the Investigation of Stress · 2025
    Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
  19. Review
  20. Designing and Teaching Courses on Sex, Gender, and the Brain: Two Implementations in the Undergraduate Classroom.Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lise EliotStanson Toshok Center for Brain Function and Repair, Chicago Medical School, Rosalind Franklin University of Medicine & Science, North Chicago, Illinois 60064 lise.eliot@rosalindfranklin.edu.
Annaliese K BeeryDepartment of Integrative Biology, University of California-Berkeley, Berkeley, California 94720.ORCID 0000-0002-1249-9182
Emily G JacobsDepartment of Psychological & Brain Sciences, University of California-Santa Barbara, Santa Barbara, California 93106.ORCID 0000-0003-0001-5096
Hannah F LeBlancDivision of the Humanities & Social Sciences, California Institute of Technology, Pasadena, California 91125.
Donna L ManeyDepartment of Psychology, Emory University, Atlanta, Georgia 30322.
Margaret M McCarthyDepartment of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland 21201.ORCID 0000-0003-2243-4726

Funding

Neuro HPA Project 1U54AG062334 · NIA · EMORY UNIVERSITY · PI Cecile Delille Lahiri, Vasiliki Michopoulos · 2018 to 2026
$12.2M
Neuroinflammation, Epigenetics and Male VulnerabilityR01MH052716 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI MARGARET M. MCCARTHY · 2000 to 2026
$9.6M
Impact of ovarian hormone suppression on regional and global brain architecture and cognitionR01AG063843 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JACOBS, EMILY G, PANIZZON, MATTHEW S · 2020 to 2024
$4.8M
Endocannabinoids regulate microglia in developing brainR01DA039062 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI MARGARET M. MCCARTHY · 2016 to 2026
$4.2M
NIA NIH HHS R01 AG063843NIA NIH HHS U54 AG062334NIDA NIH HHS R01 DA039062NIMH NIH HHS R01 MH052716
6 · The paper itself

Abstract

Long overlooked in neuroscience research, sex and gender are increasingly included as key variables potentially impacting all levels of neurobehavioral analysis. Still, many neuroscientists do not understand the difference between the terms "sex" and "gender," the complexity and nuance of each, or how to best include them as variables in research designs. This TechSights article outlines rationales for considering the influence of sex and gender across taxa, and provides technical guidance for strengthening the rigor and reproducibility of such analyses. This guidance includes the use of appropriate statistical methods for comparing groups as well as controls for key covariates of sex (e.g., total intracranial volume) and gender (e.g., income, caregiver stress, bias). We also recommend approaches for interpreting and communicating sex- and gender-related findings about the brain, which have often been misconstrued by neuroscientists and the lay public alike.

Indexed as

Behavioral ResearchNeurosciencesBrainFemaleHumansMaleReproducibility of Resultsanti-sexismfemale inclusiongender disparitysexual dimorphismstatistical analysistestosterone

Identifiers

PMID37704386
PMCPMC10500996

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.