Evidence map›Paper›PMID 37706232›Full record

ArticleAmerican journal of physiology. Renal physiology2023

Male kidney-specific BMAL1 knockout mice are protected from K

G Ryan Crislip, Hannah M Costello, Alexandria Juffre, Kit-Yan Cheng, I Jeanette Lynch, Jermaine G Johnston, Charles B Drucker, Phillip Bratanatawira, Annanya Agarwal, Victor M Mendez and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
6.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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  7. Recent advances in understanding the kidney circadian clock mechanism.American journal of physiology. Renal physiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

G Ryan CrislipDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.
Hannah M CostelloDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.
Alexandria JuffreDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.
Kit-Yan ChengDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.
I Jeanette LynchDivision of Nephrology, Hypertension, and Renal Transplantation, Department of Medicine, University of Florida, Gainesville, Florida, United States.
Jermaine G JohnstonDivision of Nephrology, Hypertension, and Renal Transplantation, Department of Medicine, University of Florida, Gainesville, Florida, United States.
Charles B DruckerDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.
Phillip BratanatawiraDivision of Nephrology, Hypertension, and Renal Transplantation, Department of Medicine, University of Florida, Gainesville, Florida, United States.
Annanya AgarwalDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, Florida, United States.
Victor M MendezDivision of Nephrology, Hypertension, and Renal Transplantation, Department of Medicine, University of Florida, Gainesville, Florida, United States.
Ryanne S ThelwellDivision of Nephrology, Hypertension, and Renal Transplantation, Department of Medicine, University of Florida, Gainesville, Florida, United States.
Lauren G DoumaDivision of Nephrology, Hypertension, and Renal Transplantation, Department of Medicine, University of Florida, Gainesville, Florida, United States.ORCID 0000-0001-8216-9253
Charles S WingoDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.
Abdel A AlliDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.ORCID 0000-0003-4381-1172
Yogesh M ScindiaDivision of Nephrology, Hypertension, and Renal Transplantation, Department of Medicine, University of Florida, Gainesville, Florida, United States.ORCID 0000-0001-6382-6289
Michelle L GumzDepartment of Physiology and Aging, University of Florida, Gainesville, Florida, United States.ORCID 0000-0002-1342-0878
University of Florida · US

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Peihua Qiu · 2007 to 2026
$22.8M
Multidisciplinary Training Program in HypertensionT32HL083810 · NHLBI · UNIVERSITY OF FLORIDA · PI WOOD, CHARLES E · 2007 to 2017
$2.5M
The circadian clock protein BMAL and post-translational regulation of ENaC in the kidneyR01DK123078 · NIDDK · UNIVERSITY OF FLORIDA · PI ALLI, ABDEL AYUBE · 2020 to 2024
$1.7M
Per1 and the kidney clock in hypertensionR01DK109570 · NIDDK · UNIVERSITY OF FLORIDA · PI GUMZ, MICHELLE L · 2017 to 2021
$1.5M
Renal Circadian Clock Protein Regulation of Immune ActivationK01DK135929 · NIDDK · UNIVERSITY OF FLORIDA · PI Gene Ryan Crislip · 2024 to 2026
$415k
The Role of Sex Hormones in Distal Nephron-Specific BMAL1 Blood Pressure Regulation in Male and Female MiceF32DK121424 · NIDDK · UNIVERSITY OF FLORIDA · PI CRISLIP, GENE RYAN · 2019 to 2021
$130k
NHLBI NIH HHS T32 HL083810NIA NIH HHS P30 AG028740NIDDK NIH HHS F32 DK121424NIDDK NIH HHS K01 DK135929NIDDK NIH HHS R01 DK109570NIDDK NIH HHS R01 DK123078
6 · The paper itself

Abstract

The circadian clock protein basic helix-loop-helix aryl hydrocarbon receptor nuclear translocator-like protein 1 (BMAL1) is a transcription factor that impacts kidney function, including blood pressure (BP) control. Previously, we have shown that male, but not female, kidney-specific cadherin Cre-positive BMAL1 knockout (KS-BMAL1 KO) mice exhibit lower BP compared with littermate controls. The goal of this study was to determine the BP phenotype and immune response in male KS-BMAL1 KO mice in response to a low-K

Indexed as

ARNTL Transcription FactorsHypertensionAnimalsBlood PressureCircadian RhythmCytokinesDietKidneyMaleMiceMice, KnockoutSodium Chloride, DietaryARNTL Transcription FactorsBmal1 protein, mouseCytokinesSodium Chloride, Dietarycircadian rhythmclockhypertensionimmune cellsinflammation

Identifiers

PMID37706232
PMCPMC10874679
OpenAlexW4386726824

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.