Effect of insulin on IR and GLP1-R expressions in HT22 cells.

Melek Tunc-Ata, Zeynep Mine Altunay, Aysel Alphan, Vural Kucukatay

Abstract read

In one paragraph

Article in Medical oncology (Northwood, London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Melek Tunc-AtaDepartment of Physiology, Faculty of Medicine, Pamukkale University, Denizli, Turkey. melekt@pau.edu.tr.ORCID http://orcid.org/0000-0002-0384-2356

Zeynep Mine AltunayDepartment of Neuroscience, School of Medicine, University of Connecticut, Farmington, CT, USA.

Aysel AlphanDepartment of Neuroscience, Institute of Health Sciences, Pamukkale University, Denizli, Turkey.

Vural KucukatayDepartment of Physiology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.

Funding

Pamukkale Üniversitesi 2022HZDP013

6 · The paper itself

Abstract

Insulin is a significant growth factor that specifically binds to the insulin receptor (IR) in the brain and then activates the PI3K-AKT pathway. Glucagon-like peptide 1 (GLP-1) has a variety of functions including neuroprotection, support for neurogenesis, and increasing insulin signal. This study aims to investigate the effect of insulin administered to immortalized clonal mouse hippocampal cell line (HT22) at different doses and intervals on IR, insulin receptor A (IRA), insulin receptor B (IRB), and Glucagon-like peptide 1 receptor (GLP1-R) mRNA expression and protein levels. The cells were planted in 6 well plates at a density of 3 × 10

Indexed as

InsulinReceptor, InsulinAnimalsGlucagon-Like Peptide 1MicePhosphatidylinositol 3-KinasesRNA, MessengerGlucagon-Like Peptide 1InsulinPhosphatidylinositol 3-KinasesReceptor, InsulinRNA, MessengerGlucagon-like peptide-1 receptorHT22 cell lineInsulin receptor

Identifiers

PMID37712993

DOI10.1016/j.cell.2016.03.014

What Socratic holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.