ArticleCNS neuroscience & therapeutics2024
Role of TRPV1 in electroacupuncture-mediated signal to the primary sensory cortex during regulation of the swallowing function.
Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 5 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 5 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Data mining of acupoint selection and combination patterns for dysphagia with sialorrhea: a literature-based study.Frontiers in neurology · 2026Pooled it
- Neuromuscular-related interventions for post-stroke dysphagia: a comprehensive narrative review.Frontiers in neuroscience · 2026Pooled it
- The efficacy of acupuncture for post-stroke dysphagia: an overview of systematic reviews and meta-analyses.Frontiers in neuroscience · 2025Pooled it
- Systematic review and meta-analysis of specific external Chinese herbal medicines for post-stroke dysphagia: efficacy and clinical implications.Frontiers in pharmacology · 2025Pooled it
- Systematic review and meta-analysis of the efficacy and safety of electroacupuncture for poststroke dysphagia.Frontiers in neurology · 2023Pooled it
- Effects of Acupuncture Combined with Conventional Rehabilitation Training for Patients with Post-Stroke Dysphagia: A Randomized Controlled Trial.Journal of multidisciplinary healthcare · 2025Trial
- Fiber-Electrospun Hydrogel Therapy for DNP: A synergistic electrospun-hydrogel composite for alleviating diabetic neuropathic pain via MMP9 regulation and sodium channel inhibition.Bioengineering & translational medicine · 2026Article
- Electroacupuncture-based vagal stimulation attenuates epileptic seizures through a body-brain circuit.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Skin-Brain Axis: neural pathways in acupuncture treatment.Chinese medicine · 2025Review
- The involvement of 5-HT was necessary for EA-mediated improvement of post-stroke depression.Translational psychiatry · 2025Article
- Astrocyte inhibition and PV interneuron activation: key mechanisms in electroacupuncture's effect on pain-anxiety comorbidity.Chinese medicine · 2025Article
- Sensory Afferent Neural Circuits Mediate Electroacupuncture to Improve Swallowing Function in a Post-Stroke Dysphagia Mouse Model.CNS neuroscience & therapeutics · 2025Article
- The effect and optimal parameters of electroacupuncture on post-stroke dysphagia: a meta-analysis of randomized controlled trials.Frontiers in neurology · 2025Review
- Review
- Role of TRPV1 in electroacupuncture-mediated signal to the primary sensory cortex during regulation of the swallowing function.CNS neuroscience & therapeutics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 3 institutions in 1 country.
Funding
Abstract
aimsElectroacupuncture (EA) at the Lianquan (CV23) could alleviate swallowing dysfunction. However, current knowledge of its neural modulation focused on the brain, with little evidence from the periphery. Transient receptor potential channel vanilloid subfamily 1 (TRPV1) is an ion channel predominantly expressed in sensory neurons, and acupuncture can trigger calcium ion (Ca
methodsBlood perfusion was evaluated by laser speckle contrast imaging (LSCI), and neuronal activity was evaluated by fiber calcium recording and c-Fos staining. The expression of TRPV1 was detected by RNA-seq analysis, immunofluorescence, and ELISA. In addition, the swallowing function was assessed by in vivo EMG recording and water consumption test.
resultsEA treatment potentiated blood perfusion and neuronal activity in the S1, and this potentiation was absent after injecting lidocaine near CV23. TRPV1 near CV23 was upregulated by EA-CV23. The blood perfusion at CV23 was decreased in the TRPV1 hypofunction mice, while the blood perfusion and the neuronal activity of the S1 showed no obvious change. These findings were also present in post-stroke dysphagia (PSD) mice.
conclusionThe TRPV1 at CV23 after EA treatment might play a key role in mediating local blood perfusion but was not involved in transferring EA signals to the central nervous system (CNS). These findings collectively suggested that TRPV1 may be one of the important regulators involved in the mechanism of EA treatment for improving swallowing function in PSD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.