Evidence map›Paper›PMID 37719112›Full record

ArticlePeerJ2023

Effect of apatinib on the pharmacokinetics of tramadol and O-desmethyltramadol in rats.

Su-Su Bao, Peng-Fei Tang, Nan-Yong Gao, Zhong-Xiang Xiao, Jian-Chang Qian, Long Zheng, Guo-Xin Hu, Huan-Hai Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Su-Su Bao *Affiliated Yueqing Hospital, Wenzhou Medical University, Wenzhou, China.
Peng-Fei Tang *Affiliated Yueqing Hospital, Wenzhou Medical University, Wenzhou, China.
Nan-Yong GaoSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Zhong-Xiang XiaoAffiliated Yueqing Hospital, Wenzhou Medical University, Wenzhou, China.
Jian-Chang QianSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Long ZhengAffiliated Yueqing Hospital, Wenzhou Medical University, Wenzhou, China.
Guo-Xin HuSchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China.
Huan-Hai XuAffiliated Yueqing Hospital, Wenzhou Medical University, Wenzhou, China.
Wenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the combination of anticancer drugs and opioids is very common, apatinib and tramadol are likely to be used in combination clinically. This study evaluated the effects of apatinib on the pharmacokinetics of tramadol and its main metabolite O-desmethyltramadol in Sprague-Dawley (SD) rats and the inhibitory effects of apatinib on tramadol in rat liver microsomes (RLMs), human liver microsomes (HLMs) and recombinant human CYP2D6.1. The samples were determined by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The

Indexed as

TramadolAnimalsChromatography, LiquidCytochrome P-450 CYP2D6HumansMicrosomes, LiverPyridinesRatsRats, Sprague-DawleyTandem Mass SpectrometryapatinibCytochrome P-450 CYP2D6O-demethyltramadolPyridinesTramadolApatinibDrug inhibitionMetabolismO-desmethyltramadolPharmacokineticsTramadol

Identifiers

PMID37719112
PMCPMC10501372
OpenAlexW4386605604

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.