Evidence map›Paper›PMID 37719366›Full record

ArticleActa pharmaceutica Sinica. B2023

Brain endothelial cell-derived extracellular vesicles with a mitochondria-targeting photosensitizer effectively treat glioblastoma by hijacking the blood‒brain barrier.

Thuy Giang Nguyen Cao, Ji Hee Kang, Su Jin Kang, Quan Truong Hoang, Han Chang Kang, Won Jong Rhee, Yu Shrike Zhang, Young Tag Ko, Min Suk Shim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

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  12. Development of AGT-7: An InnovativePharmaceuticals (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thuy Giang Nguyen CaoDivision of Bioengineering, Incheon National University, Incheon 22012, Republic of Korea.
Ji Hee KangCollege of Pharmacy, Gachon University, Incheon 21936, Republic of Korea.
Su Jin KangDivision of Bioengineering, Incheon National University, Incheon 22012, Republic of Korea.
Quan Truong HoangDivision of Bioengineering, Incheon National University, Incheon 22012, Republic of Korea.
Han Chang KangDepartment of Pharmacy, Integrated Research Institute of Pharmaceutical Sciences, and BK21 PLUS Team for Creative Leader Program for Pharmacomics-based Future Pharmacy, College of Pharmacy, the Catholic University of Korea, Gyeonggi-do 14662, Republic of Korea.
Won Jong RheeDivision of Bioengineering, Incheon National University, Incheon 22012, Republic of Korea.
Yu Shrike ZhangDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.
Young Tag KoCollege of Pharmacy, Gachon University, Incheon 21936, Republic of Korea.
Min Suk ShimDivision of Bioengineering, Incheon National University, Incheon 22012, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma (GBM) is the most aggressive malignant brain tumor and has a high mortality rate. Photodynamic therapy (PDT) has emerged as a promising approach for the treatment of malignant brain tumors. However, the use of PDT for the treatment of GBM has been limited by its low blood‒brain barrier (BBB) permeability and lack of cancer-targeting ability. Herein, brain endothelial cell-derived extracellular vesicles (bEVs) were used as a biocompatible nanoplatform to transport photosensitizers into brain tumors across the BBB. To enhance PDT efficacy, the photosensitizer chlorin e6 (Ce6) was linked to mitochondria-targeting triphenylphosphonium (TPP) and entrapped into bEVs. TPP-conjugated Ce6 (TPP-Ce6) selectively accumulated in the mitochondria, which rendered brain tumor cells more susceptible to reactive oxygen species-induced apoptosis under light irradiation. Moreover, the encapsulation of TPP-Ce6 into bEVs markedly improved the aqueous stability and cellular internalization of TPP-Ce6, leading to significantly enhanced PDT efficacy in U87MG GBM cells. An

Indexed as

Blood‒brain barrierChlorin e6Extracellular vesicleGlioblastomaMitochondria-targeting photosensitizerPhotodynamic therapyTransferrin receptorTriphenylphosphonium

Identifiers

PMID37719366
PMCPMC10502277

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.