Evidence map›Paper›PMID 37719871›Full record

ArticleFrontiers in aging neuroscience2023

Disconnectome associated with progressive white matter hyperintensities in aging: a virtual lesion study.

Meng Li, Mohamad Habes, Hans Grabe, Yan Kang, Shouliang Qi, John A Detre

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Meng LiCollege of Medicine and Biological Information Engineering, Northeastern University, Shenyang, China.
Mohamad HabesBiggs Alzheimer's Institute, University of Texas San Antonio, San Antonio, TX, United States.
Hans GrabeDepartment of Psychiatry and Psychotherapy, University of Greifswald, Stralsund, Germany.
Yan KangCollege of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen, China.
Shouliang QiCollege of Medicine and Biological Information Engineering, Northeastern University, Shenyang, China.
John A DetreDepartment of Neurology, University of Pennsylvania, Philadelphia, PA, United States.

Funding

Multiethnic machine learning brain signatures of ADRDR01AG080821 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HABES, MOHAMAD · 2022 to 2025
$2.9M
Impact of white matter hyperintensities on structural connectivity and cognitionR21AG070434 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DETRE, JOHN A · 2020 to 2020
$446k
NIA NIH HHS R01 AG080821NIA NIH HHS R21 AG070434
6 · The paper itself

Abstract

Objective: White matter hyperintensities (WMH) are commonly seen on T2-weighted magnetic resonance imaging (MRI) in older adults and are associated with an increased risk of cognitive decline and dementia. This study aims to estimate changes in the structural connectome due to age-related WMH by using a virtual lesion approach. Methods: High-quality diffusion-weighted imaging data of 30 healthy subjects were obtained from the Human Connectome Project (HCP) database. Diffusion tractography using q-space diffeomorphic reconstruction (QSDR) and whole brain fiber tracking with 10 Results: Disconnections appeared first from the striatum to middle frontal gyrus (MFG) in the 50's, then from the thalamus to MFG in the 60's and extending to the superior frontal gyrus in the 70's, and ultimately including much more widespread cortical and hippocampal nodes in the 80's. Conclusion: Changes in the structural disconnectome due to age-related WMH can be estimated using the virtual lesion approach. The observed disconnections may contribute to the cognitive and sensorimotor deficits seen in aging.

Indexed as

agingbrain networkdiffusion tensor imagingdisconnectomemagnetic resonance imagingwhite matter hyperintensities

Identifiers

PMID37719871
PMCPMC10500060

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.