Evidence map›Paper›PMID 37720694›Full record

ArticleJournal of neurology and neurological disorders2021

ABHD6 Inhibition Rescues a Sex-Dependent Deficit in Motor Coordination in The HdhQ200/200 Mouse Model of Huntington's Disease.

J K Cao, K Viray, M Shin, K-L Hsu, K Mackie, R Westenbroek, N Stella

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of neurology and neurological disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

J K CaoDepartment of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195, USA.
K VirayDepartment of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195, USA.
M ShinDepartment of Chemistry, University of Virginia, Charlottesville, VA 22904, USA.
K-L HsuDepartment of Chemistry, University of Virginia, Charlottesville, VA 22904, USA.
K MackieDepartment of Psychological and Brain Sciences, Linda and Jack Gill Center for Biomolecular Science, Indiana University, Bloomington, IN 47405, USA.
R WestenbroekDepartment of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195, USA.
N StellaDepartment of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195, USA.

Funding

Development of Psychopathology, Psychobiology, & BehaviorT32MH015442 · NIMH · UNIVERSITY OF COLORADO DENVER · PI JASON R TREGELLAS · 1985 to 2026
$10.2M
Endocannabinoid Biosynthesis in Inflammation and PainR01DA043571 · NIDA · UNIVERSITY OF VIRGINIA · PI Ku-Lung Hsu · 2017 to 2026
$3.5M
Role of ABHD6 in 2-AG SignalingR01DA026430 · NIDA · UNIVERSITY OF WASHINGTON · PI STELLA, NEPHI · 2009 to 2018
$3.4M
Neuronal cannabinoidsR01DA011322 · NIDA · UNIVERSITY OF WASHINGTON · PI MACKIE, KENNETH · 1998 to 2014
$3.4M
Protein-protein interaction inhibitors as novel analgesicsR21DA037673 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI HOHMANN, ANDREA GRACE · 2013 to 2014
$429k
NIDA NIH HHS R01 DA011322NIDA NIH HHS R01 DA026430NIDA NIH HHS R01 DA043571NIDA NIH HHS R21 DA037673NIMH NIH HHS T32 MH015442
6 · The paper itself

Abstract

Huntington's Disease is associated with motor behavior deficits that are lessened by few therapeutic options. This preliminary study tested if pharmacological inhibition of α/β-hydrolase domain containing 6 (

Indexed as

ABHD6behaviorendocannabinoidsHuntington’s Diseasemouse model

Identifiers

PMID37720694
PMCPMC10503675

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.