Evidence map›Paper›PMID 37720994›Full record

ArticleGut and liver2024

Utilization of an Automated Latex Agglutination Turbidity Assay for Assessing Gastric Mucosal Alteration during

Ayush Khangai, Junko Akada, Batsaikhan Saruuljavkhlan, Boldbaatar Gantuya, Dashdorj Azzaya, Khasag Oyuntsetseg, Duger Davaadorj, Tomohisa Uchida, Takashi Matsumoto, Yoshio Yamaoka

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut and liver, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. CurrentJGH open : an open access journal of gastroenterology and hepatology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Ayush KhangaiDepartment of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Japan.ORCID 0000-0002-7604-3272
Junko AkadaDepartment of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Japan.ORCID 0000-0003-2663-9358
Batsaikhan SaruuljavkhlanDepartment of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Japan.ORCID 0000-0003-3258-4453
Boldbaatar GantuyaDepartment of Gastroenterology, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.ORCID 0000-0003-4293-0532
Dashdorj AzzayaDepartment of Gastroenterology, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.ORCID 0000-0002-8602-0023
Khasag OyuntsetsegDepartment of Gastroenterology, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.ORCID 0000-0003-3037-5922
Duger DavaadorjDepartment of Gastroenterology, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.ORCID 0000-0002-4573-8979
Tomohisa UchidaDepartment of Advanced Medical Sciences, Oita University Faculty of Medicine, Oita, Japan.ORCID 0000-0002-2646-8256
Takashi MatsumotoDepartment of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Japan.ORCID 0000-0002-6899-1686
Yoshio YamaokaDepartment of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Japan.ORCID 0000-0002-1222-5819
Oita University · JPMongolian National University · MNBaylor College of Medicine · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/Aims: : A latex agglutination turbidity (LA) assay to test for serum antibodies has been approved in Japan and Korea for mass screening of Methods: : In total, 484 individuals were classified into Results: : The best cutoff, sensitivity, and specificity values for the LA assay were 18.35 U/mL, 74.2%, and 65.6%, respectively. The LA values in the atrophic gastritis group were statistically higher than those in the other groups (healthy, chronic gastritis, intestinal metaplasia, and gastric cancer, p<0.0001). The cutoff value to distinguish the atrophic gastritis group from the other four groups was 32.0 U/mL, and its area under the curve was 0.673, which was the highest among the E-plate, pepsinogen (PG) I, PG II, and PG I/II ratio tests in our data. The odds ratios for atrophic gastritis determined by the LA assay and PG I test in multiple logistic regression were 2.5 and 1.9, respectively, which were significantly higher than for the other tests. Conclusions: : The LA assay can determine the risk of atrophic gastritis, which in turn is a considerable risk factor for gastric cancer. We propose using this assay in combination with the PG I/II ratio to avoid missing gastric cancer patients who have a low LA value (less than 32.0 U/mL).

Indexed as

Gastritis, AtrophicHelicobacter InfectionsHelicobacter pyloriStomach NeoplasmsHumansLatex Fixation TestsPepsinogen APepsinogen CPepsinogen APepsinogen CAtrophic gastritisE-plateHelicobacter pyloriLatex agglutination testMongolia

Identifiers

PMID37720994
PMCPMC10791506
OpenAlexW4386818458

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.