Evidence map›Paper›PMID 37722038›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

An intraflagellar transport dependent negative feedback regulates the MAPKKK DLK-1 to protect cilia from degeneration.

Yue Sun, Yishi Jin

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. A tubulin-MAPKKK pathway engages tubulin isotype interaction for neuroprotection.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Loss of function inmicroPublication biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yue SunDepartment of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093.ORCID 0000-0003-0042-1908
Yishi JinDepartment of Neurobiology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093.ORCID 0000-0002-9371-9860
University of California San Diego · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Molecular genetics of axon and synapse development and maintenanceR35NS127314 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Yishi Jin · 2022 to 2026
$4.3M
GABAergic Neuron Differentiation in C.elegansR37NS035546 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JIN, YISHI · 2017 to 2021
$2.4M
NIH HHS P40 OD010440NINDS NIH HHS R35 NS127314NINDS NIH HHS R37 NS035546
6 · The paper itself

Abstract

Primary cilia are specialized organelles supporting the development and function of cells and organisms. Intraflagellar transport (IFT) is essential for cilia formation, maintenance, and function. In

Indexed as

Caenorhabditis elegans ProteinsCiliaAnimalsAxonsCaenorhabditis elegansFeedbackMAP Kinase Kinase KinasesNerve RegenerationSensory Receptor CellsCaenorhabditis elegans ProteinsDLK-1 protein, C elegansMAP Kinase Kinase KinasesAWC sensory neuronCEBP-1 bZIP proteinCHE-10 RootletinCHE-3 dyneincilia degeneration

Identifiers

PMID37722038
PMCPMC10523469
OpenAlexW4386824160

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.