Evidence map›Paper›PMID 37722652›Full record

ArticleExperimental hematology2023

Physiological and regenerative functions of sterile-α motif protein-14 in hematopoiesis.

Meg A Schaefer, Pooja Roy, Srinivas Chava, Ainsley Meyerson, Andrew L Duncan, Linda Chee, Kyle J Hewitt

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental hematology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Meg A SchaeferDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE.
Pooja RoyDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE.
Srinivas ChavaDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE.
Ainsley MeyersonDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE.
Andrew L DuncanDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE.
Linda CheeDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE.
Kyle J HewittDepartment of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE. Electronic address: kyle.hewitt@unmc.edu.
University of Nebraska Medical Center · USNebraska Medical Center · US

Funding

UNMC Structural Biology CoreP20GM103427 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PAUL L SORGEN · 2012 to 2026
$59.2M
UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI James Eudy · 1985 to 2026
$55.0M
Target Validation CoreP20GM121316 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI ADRIAN R BLACK · 2018 to 2026
$23.5M
GATA Factor Mechanisms in Erythroid RegenerationR01HL155439 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI HEWITT, KYLE J · 2021 to 2025
$1.9M
Mechanisms of a GATA Factor-Dependent Hematopoietic Signaling PathwayK01DK113117 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI HEWITT, KYLE J · 2017 to 2018
$199k
NCI NIH HHS P30 CA036727NHLBI NIH HHS R01 HL155439NIDDK NIH HHS K01 DK113117NIGMS NIH HHS P20 GM103427NIGMS NIH HHS P20 GM121316
6 · The paper itself

Abstract

Sterile α-motif domain-14 (Samd14) protein expression increases the regenerative capacity of the erythroid system. Samd14 is transcriptionally upregulated and promotes cell signaling via the receptor tyrosine kinase Kit in a critical window of acute erythroid regeneration. We generated a hematopoietic-specific conditional Samd14 knockout mouse model (Samd14-CKO) to study the role of Samd14 in hematopoiesis. The Samd14-CKO mouse was viable and exhibited no steady-state hematopoietic phenotype. Samd14-CKO mice were hypersensitive to 5-fluorouracil, resulting in more severe anemia during recovery and impaired erythroid progenitor colony formation. Ex vivo, Samd14-CKO hematopoietic progenitors were defective in their ability to form mast cells. Samd14-CKO mast cells exhibited altered Kit/stem cell factor (SCF), IL-3/IL-3R signaling, and less granularity than Samd14-FL/FL cells. Our findings indicate that Samd14 promotes both erythroid and mast cell functions. The Samd14-CKO mouse phenotype exhibits striking similarities to the Kit

Indexed as

AnemiaCytoskeletal ProteinsHematopoiesisAnimalsMiceProteinsProto-Oncogene Proteins c-kitReceptor Protein-Tyrosine KinasesSignal TransductionStem Cell FactorCytoskeletal ProteinsProteinsProto-Oncogene Proteins c-kitReceptor Protein-Tyrosine KinasesSamd14 protein, mouseStem Cell Factor

Identifiers

PMID37722652
PMCPMC10947990
OpenAlexW4386797673

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.