Evidence map›Paper›PMID 37724511›Full record

ArticleThe Journal of eukaryotic microbiology

Gene editing of putative cAMP and Ca

Miguel A Chiurillo, Milad Ahmed, César González, Aqsa Raja, Noelia Lander

Open access · hybridAbstract read
In one paragraph

Article in The Journal of eukaryotic microbiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Cloning-Free Genome Editing by CRISPR/T7RNAP/Cas9 in Trypanosoma cruzi.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. The intersection of hostMicrobiology and molecular biology reviews : MMBR · 2024
    Review
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Miguel A ChiurilloDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio, USA.ORCID 0000-0002-5581-9027
Milad AhmedDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio, USA.
César GonzálezDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio, USA.
Aqsa RajaDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio, USA.
Noelia LanderDepartment of Biological Sciences, University of Cincinnati, Cincinnati, Ohio, USA.ORCID 0000-0003-2178-381X
University of Cincinnati · US

Funding

Large-scale CRISPR screening of essential calcium-related genes in the human parasite Tr. cruziR00AI137322 · NIAID · UNIVERSITY OF CINCINNATI · PI LANDER, NOELIA · 2021 to 2022
$498k
Barcode screening of essential protein kinases in the life cycle progression of Trypanosoma cruziR21AI178573 · NIAID · UNIVERSITY OF CINCINNATI · PI CHIURILLO, MIGUEL A · 2023 to 2024
$446k
American Heart Association-American Stroke Association 23IPA1054779NIAID NIH HHS R00 AI137322NIAID NIH HHS R21 AI178573
6 · The paper itself

Abstract

Trypanosoma cruzi, the agent of Chagas disease, must adapt to a diversity of environmental conditions that it faces during its life cycle. The adaptation to these changes is mediated by signaling pathways that coordinate the cellular responses to the new environmental settings. Cyclic AMP (cAMP) and Calcium (Ca

Indexed as

Chagas DiseaseTrypanosoma cruziCRISPR-Cas SystemsGene EditingHumansProtozoan ProteinsProtozoan Proteinscalcium ionscyclic AMPessential genesgenome editingtrypanosomes

Identifiers

PMID37724511
PMCPMC10841170
OpenAlexW4386843467

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.