Evidence map›Paper›PMID 37725136›Full record

ArticleExperimental brain research2023

Effect of electrical and chemical (activation versus inactivation) stimulation of the infralimbic division of the medial prefrontal cortex in rats with chronic neuropathic pain.

Thais Lohanny Moura-Pacheco, Renata Cristina Martins-Pereira, Priscila Medeiros, Lourenço Sbragia, Christie Ramos Andrade Leite-Panissi, Hélio Rubens Machado, Norberto Cysne Coimbra, Renato Leonardo de Freitas

Abstract read
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In one paragraph

Article in Experimental brain research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Thais Lohanny Moura-PachecoMulti-User Center of Neuroelectrophysiology, Department of Surgery and Anatomy, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, SP, 14049-900, Brazil.
Renata Cristina Martins-PereiraMulti-User Center of Neuroelectrophysiology, Department of Surgery and Anatomy, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, SP, 14049-900, Brazil.
Priscila MedeirosMulti-User Center of Neuroelectrophysiology, Department of Surgery and Anatomy, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, SP, 14049-900, Brazil.
Lourenço SbragiaPediatric Surgery Laboratory, Department of Surgery and Anatomy, FMRP-USP, Av. Bandeirantes, 3900, Ribeirão Preto, SP, 14049-900, Brazil.
Christie Ramos Andrade Leite-PanissiDepartment of Psychology,, Faculty of Philosophy, Science and Letters of Ribeirão Preto of the University of São Paulo (FFCLRP-USP), Ribeirão Preto, SP, 14040-901, Brazil.
Hélio Rubens MachadoMulti-User Center of Neuroelectrophysiology, Department of Surgery and Anatomy, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, SP, 14049-900, Brazil.
Norberto Cysne CoimbraMulti-User Center of Neuroelectrophysiology, Department of Surgery and Anatomy, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, SP, 14049-900, Brazil.
Renato Leonardo de FreitasMulti-User Center of Neuroelectrophysiology, Department of Surgery and Anatomy, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes, 3900, Ribeirão Preto, SP, 14049-900, Brazil. defreitas.rl@gmail.com.ORCID http://orcid.org/0000-0003-1799-5326
Universidade de São Paulo · BRUniversidade de Ribeirão Preto · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo Multi-user Equipment Grant 2014/11869- 0Fundação de Amparo à Pesquisa do Estado de São Paulo Research Grant 2013/12916-0
6 · The paper itself

Abstract

Neuropathic pain (NP) represents a complex disorder with sensory, cognitive, and emotional symptoms. The medial prefrontal cortex (mPFC) takes critical regulatory roles and may change functionally and morphologically during chronic NP. There needs to be a complete understanding of the neurophysiological and psychopharmacological bases of the NP phenomenon. This study aimed to investigate the participation of the infralimbic division (IFL) of the mPFC in chronic NP, as well as the role of the N-methyl-D-aspartic acid receptor (NMDAr) in the elaboration of chronic NP. Male Wistar rats were submitted to the von Frey and acetone tests to assess mechanical and cold allodynia after 21 days of chronic constriction injury (CCI) of the sciatic nerve or Sham-procedure ("false operated"). Electrical neurostimulation of the IFL/mPFC was performed by low-frequency stimuli (20 μA, 100 Hz) applied for 15 s by deep brain stimulation (DBS) device 21 days after CCI. Either cobalt chloride (CoCl

Indexed as

HyperalgesiaNeuralgiaAnimalsCobaltMaleN-MethylaspartatePain MeasurementPrefrontal CortexRatsRats, WistarReceptors, N-Methyl-D-AspartateCobaltcobaltous chlorideN-MethylaspartateReceptors, N-Methyl-D-AspartateAnalgesiaCerebral cortex neurostimulationChronic neuropathic painCobalt chlorideGlutamatergic NMDA receptorInfralimbic medial prefrontal cortex

Identifiers

PMID37725136
OpenAlexW4386847837

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.