Evidence map›Paper›PMID 37725642›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Allostatic load in children: The cost of empathic concern.

Desiree Y Phua, Helen Chen, Fabian Yap, Yap Seng Chong, Peter D Gluckman, Birit F P Broekman, Johan G Eriksson, Michael J Meaney

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Reflections on resilience.Development and psychopathology · 2024
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 5 countries.

Desiree Y PhuaTranslational Neuroscience Programme, Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore 117609, Republic of Singapore.ORCID 0000-0001-6055-656X
Helen ChenDepartment of Psychological Medicine, Kandang Kerbau Women's and Children's Hospital, Singapore 229899, Republic of Singapore.
Fabian YapDepartment of Psychological Medicine, Kandang Kerbau Women's and Children's Hospital, Singapore 229899, Republic of Singapore.
Yap Seng ChongTranslational Neuroscience Programme, Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore 117609, Republic of Singapore.
Peter D GluckmanTranslational Neuroscience Programme, Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore 117609, Republic of Singapore.ORCID 0000-0002-5711-1655
Birit F P BroekmanDepartment of Psychiatry, Amsterdam University Medical Centers (UMC) and Onze Lieve Vrouwe Gasthuis (OLVG), Vrije Universiteit (VU), Amsterdam 1081 HV, The Netherlands.ORCID 0000-0003-1461-4241
Johan G ErikssonTranslational Neuroscience Programme, Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore 117609, Republic of Singapore.ORCID 0000-0002-2516-2060
Michael J MeaneyTranslational Neuroscience Programme, Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore 117609, Republic of Singapore.
Agency for Science, Technology and Research · SGKK Women's and Children's Hospital · SGNational University of Singapore · SGOLVG · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early-life adversity affects long-term health outcomes but there is considerable interindividual variability in susceptibility to environmental influences. We proposed that positive psychological characteristics that reflect engagement with context, such as being concerned about people or performance on tasks (i.e., empathic concern), could moderate the interindividual variation in sensitivity to the quality of the early environment. We studied 526 children of various Asian nationalities in Singapore (46.6% female, 13.4% below the poverty line) with longitudinal data on perinatal and childhood experiences, maternal report on empathic concern of the child, and a comprehensive set of physiological measures reflecting pediatric allostatic load assessed at 6 y of age. The perinatal and childhood experiences included adversities and positive experiences. We found that cumulative adverse childhood experience was positively associated with allostatic load of children at 6 y of age at higher levels of empathic concern but not significantly associated at lower levels of empathic concern. This finding reveals evidence for the importance of empathic concern as a psychological characteristic that moderates the developmental impact of environmental influences, serving as a source for vulnerability to adversities in children.

Indexed as

Adverse Childhood ExperiencesAllostasisAsianChildEmpathyFamilyFemaleHumansMalePregnancyallostasiscaringdiathesis-stressdifferential susceptibilityearly-life stress

Identifiers

PMID37725642
PMCPMC10523447
OpenAlexW4386859213

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.