Evidence map›Paper›PMID 37726169›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2023

Tonic Activation of NR2D-Containing NMDARs Exacerbates Dopaminergic Neuronal Loss in MPTP-Injected Parkinsonian Mice.

Ramesh Sharma, Chiranjivi Neupane, Thuy Linh Pham, Miae Lee, Sanghoon Lee, So Yeong Lee, Min-Ho Nam, Cuk-Seong Kim, Jin Bong Park

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Structural prediction of GluN3 NMDA receptors.Frontiers in physiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Ramesh SharmaDepartment of Biomedicine, Chungnam National University, Daejeon 35015, Republic of Korea.ORCID 0000-0002-8563-6109
Chiranjivi NeupaneDepartment of Biomedicine, Chungnam National University, Daejeon 35015, Republic of Korea.ORCID 0000-0003-2719-9331
Thuy Linh PhamDepartment of Biomedicine, Chungnam National University, Daejeon 35015, Republic of Korea.
Miae LeePhysiology, Chungnam National University, Daejeon 35015, Republic of Korea.ORCID 0000-0002-2542-4884
Sanghoon LeeLaboratory of Veterinary Pharmacology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08852, Republic of Korea.
So Yeong LeeLaboratory of Veterinary Pharmacology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08852, Republic of Korea.
Min-Ho NamBrain Science Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
Cuk-Seong KimDepartment of Biomedicine, Chungnam National University, Daejeon 35015, Republic of Korea.
Jin Bong ParkLaboratory of Veterinary Pharmacology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08852, Republic of Korea jbpark@snu.ac.kr.
Seoul National University · KRChungnam National University · KRKorea Institute of Brain Science · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NR2D subunit-containing NMDA receptors (NMDARs) gradually disappear during brain maturation but can be recruited by pathophysiological stimuli in the adult brain. Here, we report that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication recruited NR2D subunit-containing NMDARs that generated an Mg

Indexed as

Parkinson DiseaseReceptors, N-Methyl-D-Aspartate1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAnimalsDopamineDopaminergic NeuronsMaleMiceMice, Inbred C57BLN-MethylaspartateSubstantia Nigra1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineDopamineN-MethylaspartateReceptors, N-Methyl-D-Aspartatedopaminergic neuronsMPTPNR2DSNpctonic NMDA

Identifiers

PMID37726169
PMCPMC10648527
OpenAlexW4386859408

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.