Evidence map›Paper›PMID 37727203›Full record

ArticleFrontiers in oncology2023

Changes in gut microbiota composition after 12 weeks of a home-based lifestyle intervention in breast cancer survivors during the COVID-19 lockdown.

Sabrina Donati Zeppa, Valentina Natalucci, Deborah Agostini, Luciana Vallorani, Stefano Amatori, Davide Sisti, Marco B L Rocchi, Valerio Pazienza, Francesco Perri, Annacandida Villani and 15 more

Registry-linked trialAbstract read
In one paragraph

Article in Frontiers in oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04818359 (Movement and Health Beyond Care, MoviS), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04818359 naunknown statusnot on this map

Movement and Health Beyond Care, MoviS: Nutrition and Exercise Educational Programs for Breast Cancer Survivors

TypeinterventionalSponsorUniversity of Urbino "Carlo Bo"Ran2020 to 2025Enrolled172ConditionsBreast Cancer SurvivorsArmsMoviS Training
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Effects of exercise on gut microbiota in patients with cancer: a scoping review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Exercise and the gut microbiome: implications for supportive care in cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Sabrina Donati ZeppaDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Valentina NatalucciDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Deborah AgostiniDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Luciana ValloraniDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Stefano AmatoriDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Davide SistiDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Marco B L RocchiDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Valerio PazienzaDivision of Gastroenterology, Fondazione IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Italy.
Francesco PerriDivision of Gastroenterology, Fondazione IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Italy.
Annacandida VillaniDivision of Gastroenterology, Fondazione IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Italy.
Elena BindaCancer Stem Cells Unit, Institute for Stem Cell Biology, Regenerative Medicine and Innovative Therapeutics (ISBReMIT), IRCSS Casa Sollievo della Sofferenza, Opera di San Pio da Pietrelcina, San Giovanni Rotondo, Italy.
Concetta PanebiancoDivision of Gastroenterology, Fondazione IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Italy.
Gandino MencarelliCancer Stem Cells Unit, Institute for Stem Cell Biology, Regenerative Medicine and Innovative Therapeutics (ISBReMIT), IRCSS Casa Sollievo della Sofferenza, Opera di San Pio da Pietrelcina, San Giovanni Rotondo, Italy.
Luigi CiuffredaBreast Surgery Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.
Carlo Ferri MariniDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Giosué AnnibaliniDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Francesco LucertiniDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Alessia BartolacciDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Marta ImperioDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Edy VirgiliSchool of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Italy.
Vincenzo CatalanoU.O.C. Oncologia Medica, ASUR Area Vasta 1, Ospedale Santa Maria della Misericordia di Urbino, Urbino, Italy.
Giovanni PiccoliDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Vilberto StocchiUniversità Telematica San Raffaele, Rome, Italy.
Rita EmiliU.O.C. Oncologia Medica, ASUR Area Vasta 1, Ospedale Santa Maria della Misericordia di Urbino, Urbino, Italy.
Elena BarbieriDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Breast cancer (BC) is the second-leading cause of cancer-related death worldwide. This study aimed to investigate the effects of a 12-week home-based lifestyle intervention (based on nutrition and exercise) on gut microbial composition in twenty BC survivors of the MoviS clinical trial (protocol: NCT04818359). Methods: Gut microbiota analysis through 16S rRNA gene sequencing, anthropometrics, Mediterranean Diet (MD) adherence, and cardiometabolic parameters were evaluated before (Pre) and after (Post) the lifestyle intervention (LI). Results: Beneficial effects of the LI were observed on MD adherence, and cardiometabolic parameters (pre vs post). A robust reduction of Proteobacteria was observed after LI, which is able to reshape the gut microbiota by modulating microorganisms capable of decreasing inflammation and others involved in improving the lipid and glycemic assets of the host. A significant negative correlation between fasting glucose and Conclusion: These data suggest that adopting a healthy lifestyle, may contribute to ameliorate several biological parameters that could be involved in the prevention of cancer relapses through the modulation of gut microbiota.

Indexed as

breast cancer survivorsCOVID-19gut microbiotaMediterranean dietphysical exercise

Identifiers

PMID37727203
PMCPMC10505708

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.