Evidence map›Paper›PMID 37728457›Full record

ArticlePediatric endocrinology, diabetes, and metabolism2023

Assessment of fibroblast growth factor 21 in children with type 1 diabetes mellitus in relation to microvascular complications.

Nermien Tantawy, Eman Sherif, Randa M Matter, Nouran Salah, Nour Eldin Abozeid, Heba Atif

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Article in Pediatric endocrinology, diabetes, and metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Nermien TantawyPaediatrics Department, Paediatric and Adolescent Diabetes Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Eman SherifPaediatrics Department, Paediatric and Adolescent Diabetes Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Randa M MatterPaediatrics Department, Paediatric and Adolescent Diabetes Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Nouran SalahPaediatrics Department, Paediatric and Adolescent Diabetes Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Nour Eldin AbozeidOpthalmology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Heba AtifClinical Pathology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionType 1 diabetes mellitus (DM1) represents a growing global health problem with significant morbidity. Fibroblast growth factor 21 (FGF21) is an adipokine expressed predominantly in the liver that plays an important role in metabolic regulation. AIM OF THE STUDY: This study assesses FGF21 levels in children with DM1, in comparison to controls, and correlates them with diabetes duration, glycated haemoglobin (HbA1c), and diabetic microvascular complications. MATERIAL AND

methodsFifty children with DM1, aged between 5 and 16 years, were studied regarding their diabetes duration, HbA1c, urinary albumin creatinine ratio (UACR), fundus, and FGF21 level. They were compared to 50 healthy controls.

resultsThe median FGF21 of the studied children with DM1 was 150 pg/ml, range 50-350 pg/ml; while that of the controls was 35 pg/ml, range 20-50 pg/ml. FGF21 level was significantly higher in children with DM1 than in controls ( p < 0.001). Moreover, it was significantly and positively correlated with diabetes duration, mean blood glucose level, and HbA1c ( p < 0.001, p = 0.015, p = 0.018, respectively). Interestingly, the FGF21 level was not significantly elevated in children with DM1 having diabetic nephropathy and retinopathy ( p = 0.122, p = 0.298, respectively).

conclusionsFGF21 is significantly higher among children with DM1 than in controls. However, its role in diabetic microvascular complica-tions needs further assessment.

Indexed as

Diabetes Mellitus, Type 1Diabetic NephropathiesAdolescentChildChild, PreschoolFibroblast Growth FactorsGlycated HemoglobinHumansFGF21 protein, humanfibroblast growth factor 21Fibroblast Growth FactorsGlycated HemoglobinchildrenFGF21type 1 diabetes mellitus

Identifiers

PMID37728457
PMCPMC10411091

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.