Evidence map›Paper›PMID 37729021›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2023

Both moderate- and high-intensity exercise training increase intramyocellular lipid droplet abundance and modify myocellular distribution in adults with obesity.

Michael W Schleh, Cheehoon Ahn, Benjamin J Ryan, Olivia K Chugh, Austin T Luker, Kathryn E Luker, Jenna B Gillen, Alison C Ludzki, Douglas W Van Pelt, Lisa M Pitchford and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 2 countries.

Michael W SchlehSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States.ORCID 0000-0001-9969-6316
Cheehoon AhnSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States.ORCID 0000-0003-4140-125X
Benjamin J RyanSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States.ORCID 0000-0001-5848-6988
Olivia K ChughSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States.
Austin T LukerSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States.
Kathryn E LukerDepartment of Radiology, Center for Molecular Imaging, University of Michigan, Ann Arbor, Michigan, United States.
Jenna B GillenSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States.ORCID 0000-0001-7974-5395
Alison C LudzkiSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States.ORCID 0000-0002-6967-034X
Douglas W Van PeltSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States.ORCID 0000-0001-9594-604X
Lisa M PitchfordSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States.
Tao ZhangSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States.
Thomas RodeSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States.
Suzette M HowtonSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States.
Charles F BurantDivision of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, United States.
Jeffrey F HorowitzSubstrate Metabolism Laboratory, School of Kinesiology, University of Michigan, Ann Arbor, Michigan, United States.ORCID 0000-0003-3851-777X
University of Michigan · USUniversity of Toronto · CA

Funding

Pilot and Feasibility ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2022 to 2025
$4.9M
TRAINING PROGRAM IN ENDOCRINOLOGY AND METABOLISM.T32DK007245 · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 1986 to 2005
$1.4M
Pilot and Feasibility (P and F) ProgramP30DK089503 · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2025 to 2025
$1.2M
Specialist in Multi-Scale Molecular Imaging of Tumor EnvironmentsR50CA221807 · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2025 to 2025
$217k
NCI NIH HHS R50 CA221807NIDDK NIH HHS F32 DK117522NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK089503NIDDK NIH HHS R01 DK077966NIDDK NIH HHS T32 DK007245NIDDK NIH HHS U24 DK097153
6 · The paper itself

Abstract

Exercise training modifies lipid metabolism in skeletal muscle, but the effect of exercise training on intramyocellular lipid droplet (LD) abundance, size, and intracellular distribution in adults with obesity remains elusive. This study compared high-intensity interval training (HIIT) with more conventional moderate-intensity continuous training (MICT) on intramyocellular lipid content, as well as LD characteristics (size and number) and abundance within the intramyofibrillar (IMF) and subsarcolemmal (SS) regions of type I and type II skeletal muscle fibers in adults with obesity. Thirty-six adults with obesity [body mass index (BMI) = 33 ± 3 kg/m

Indexed as

High-Intensity Interval TrainingLipid DropletsAdultEnergy MetabolismExerciseHumansLipidsObesityLipidsexercisehigh-intensity interval traininglipid dropletlipophagyskeletal muscle

Identifiers

PMID37729021
PMCPMC10864005
OpenAlexW4386886689

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.