Evidence map›Paper›PMID 37730398›Full record

Observational studyBMJ open2023

Prevalence and impact of chronic dysglycaemia among patients with COVID-19 in Swedish intensive care units: a multicentre, retrospective cohort study.

Anca Balintescu, Susanne Rysz, Carl Hertz, Jonathan Grip, Maria Cronhjort, Anders Oldner, Christer Svensen, Johan Mårtensson

Abstract readObservational StudyMulticenter Study
In one paragraph

Observational study in BMJ open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anca BalintescuDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institute, Stockholm, Sweden anca.balintescu@ki.se.ORCID 0000-0001-8665-5742
Susanne RyszDepartment of Perioperative Medicine and Intensive Care, Karolinska Institute, Stockholm, Sweden.
Carl HertzDepartment of Anesthesia and Intensive Care, Stockholm South General Hospital Anaesthesia, Stockholm, Sweden.
Jonathan GripDepartment of Perioperative Medicine and Intensive Care, Karolinska Institute, Stockholm, Sweden.
Maria CronhjortDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institute, Stockholm, Sweden.
Anders OldnerDepartment of Perioperative Medicine and Intensive Care, Karolinska Institute, Stockholm, Sweden.
Christer SvensenDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institute, Stockholm, Sweden.
Johan MårtenssonDepartment of Perioperative Medicine and Intensive Care, Karolinska Institute, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveUsing glycated haemoglobin A1c (HbA1c) screening, we aimed to determine the prevalence of chronic dysglycaemia among patients with COVID-19 admitted to the intensive care unit (ICU). Additionally, we aimed to explore the association between chronic dysglycaemia and clinical outcomes related to ICU stay.

designMulticentre retrospective observational study.

settingICUs in three hospitals in Stockholm, Sweden.

participantsCOVID-19 patients admitted to the ICU between 5 March 2020 and 13 August 2020 with available HbA1c at admission. Chronic dysglycaemia was determined based on previous diabetes history and HbA1c. PRIMARY AND SECONDARY OUTCOMES: Primary outcome was the actual prevalence of chronic dysglycaemia (pre-diabetes, unknown diabetes or known diabetes) among COVID-19 patients. Secondary outcome was the association of chronic dysglycaemia with 90-day mortality, ICU length of stay, duration of invasive mechanical ventilation (IMV) and renal replacement therapy (RRT), accounting for treatment selection bias.

resultsA total of 308 patients with available admission HbA1c were included. Chronic dysglycaemia prevalence assessment was restricted to 206 patients admitted ICUs in which HbA1c was measured on all admitted patients. Chronic dysglycaemia was present in 82.0% (95% CI 76.1% to 87.0%) of patients, with pre-diabetes present in 40.2% (95% CI 33.5% to 47.3%), unknown diabetes in 20.9% (95% CI 15.5% to 27.1%), well-controlled diabetes in 7.8% (95% CI 4.5% to 12.3%) and uncontrolled diabetes in 13.1% (95% CI 8.8% to 18.5%). All patients with available HbA1c were included for the analysis of the relationship between chronic dysglycaemia and secondary outcomes. We found no independent association between chronic dysglycaemia and 90-day mortality, ICU length of stay or duration of IMV. After excluding patients with specific treatment limitations, no association between chronic dysglycaemia and RRT use was observed.

conclusionsIn our cohort of critically ill COVID-19 patients, the prevalence of chronic dysglycaemia was 82%. We found no robust associations between chronic dysglycaemia and clinical outcomes when accounting for treatment limitations.

Indexed as

COVID-19Prediabetic StateGlycated HemoglobinHumansIntensive Care UnitsPrevalenceRetrospective StudiesSwedenGlycated HemoglobinAdult intensive & critical careCOVID-19DIABETES & ENDOCRINOLOGYGeneral diabetes

Identifiers

PMID37730398
PMCPMC10510869

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.