ArticleNature2023
Transgenic ferret models define pulmonary ionocyte diversity and function.
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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0cells of the map it votes in
53citing papers in PubMed
17.1field-weighted citation impact, top 1% of its field
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Who cites it
53 citing papers in PubMed, 66 citations in OpenAlex.
- Human Nasal and Bronchial Epithelium in Cystic Fibrosis: Differences in Expression of Airway pH Regulatory Proteins.Pediatric pulmonology · 2026Article
- Considerations for early life genetic therapies in cystic fibrosis.American journal of physiology. Lung cellular and molecular physiology · 2026Review
- Therapeutic potential of synergistic mucociliary clearance for cystic fibrosis airways by β-adrenergic plus cholinergic agonists.The Journal of clinical investigation · 2026Article
- Progenitor Resilience and the Early Onset of Chronic Lung Diseases: NHLBI workshop report.American journal of respiratory cell and molecular biology · 2026Article
- Base editing and nanoparticle transfection of airway cell types essential for treatment of cystic fibrosis.JCI insight · 2026Article
- Advances in our understanding of distal progenitors in idiopathic pulmonary fibrosis: implications for novel therapeutics.The European respiratory journal · 2026Review
- PM2.5 toxin benzo[a]pyrene induces life-limiting inflammation and oxidative stress in the airway by up-regulation of TRPC6 and inactivation of β2AR/CFTR signaling.bioRxiv : the preprint server for biology · 2026Article
- Ascl3The Journal of physiology · 2026Article
- [Research progress on epithelial mucosal barrier impairment contributing to chronic rhinosinusitis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026Review
- Integrated airway epithelial signaling networks linking allergen-driven inflammation to airway remodeling in asthma.Frontiers in immunology · 2026Review
- Ferrets and genetically modified ferrets as model organisms in biomedical research: a review.Frontiers in genome editing · 2026Review
- Cellular plasticity and regenerative mechanisms in the lung.European respiratory review : an official journal of the European Respiratory Society · 2026Review
- Specialized gas-exchange endothelium of the zebrafish gill.bioRxiv : the preprint server for biology · 2025Article
- Ferret model of bleomycin-induced lung injury shares features of human idiopathic pulmonary fibrosis.NPJ Regenerative medicine · 2025Article
- Base editing and nanoparticle transfection of airway cell types essential for treatment of cystic fibrosis.bioRxiv : the preprint server for biology · 2025Article
- Artificial intelligence-guided design of lipid nanoparticles for pulmonary gene therapy.Nature biotechnology · 2025Article
- Differential expression of villin and advillin by neuroendocrine and tuft cells in the murine lower airways.Cell and tissue research · 2025Article
- Pulmonary Ionocytes at the Crossroads of Absorption and Secretion: Clues from the Ferret.American journal of respiratory and critical care medicine · 2025Article
- Ionocyte CFTR Coordinates Chloride Absorption and Secretion to Balance Airway Fluid.American journal of respiratory and critical care medicine · 2025Article
- Novel Cystic Fibrosis Ferret Model Enables Visualization of CFTR Expression Cells and Genetic CFTR Reactivation.Human gene therapy · 2025Article
Corrections and comments
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Authors and funding
39 authors at 10 institutions in 1 country.
Feng YuanDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-5210-8510
Grace N GasserDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-2393-2674
Evan LemireDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Daniel T MontoroBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-6222-2149
Karthik JagadeeshBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Yan ZhangDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Yifan DuanDepartment of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Vitaly IevlevDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Kristen L WellsBarbara Davis Center for Childhood Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0002-7466-8164
Pavana G RottiSynthetic Biology Center, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Weam ShahinDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-8990-2013
Michael WinterDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Bradley H RosenDivision of Pulmonary, Critical Care, Occupational, and Sleep Medicine, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Idil EvansDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Qian CaiDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Miao YuDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Susan A WalshDepartment of Radiology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Michael R AcevedoDepartment of Radiology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Darpan N PandyaDepartment of Radiology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
Vamsidhar AkurathiDepartment of Radiology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
David W DickDepartment of Radiology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-2453-2429
Thaddeus J WadasDepartment of Radiology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-9913-0336
Nam Soo JooCystic Fibrosis Research Laboratory, Department of Psychology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-0510-6862
Jeffrey J WineCystic Fibrosis Research Laboratory, Department of Psychology, Stanford University, Stanford, CA, USA.
Susan BirketDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Courtney M FernandezDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Hui Min LeungWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-3259-3720
Guillermo J TearneyWellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA.
Alan S VerkmanDepartment of Medicine, UCSF, San Francisco, CA, USA.
Peter M HaggieDepartment of Medicine, UCSF, San Francisco, CA, USA.
Kathleen ScottOffice of Animal Resources, University of Iowa, Iowa City, IA, USA.
Douglas BartelsDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
David K MeyerholzDepartment of Pathology, University of Iowa, Iowa City, IA, USA.ORCID 0000-0003-1552-3253
Steven M RoweDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Xiaoming LiuDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.ORCID 0000-0002-3902-9105
Ziying YanDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.ORCID 0000-0001-8210-5567
Adam L HaberDepartment of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, USA. ahaber@hsph.harvard.edu.ORCID 0000-0002-4229-2852
Xingshen SunDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA. xingshen-sun@uiowa.edu.ORCID 0000-0003-3561-8428
John F EngelhardtDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA. john-engelhardt@uiowa.edu.ORCID 0000-0003-2389-9277
University of Iowa · USHarvard University · USUniversity of Alabama at Birmingham · USBroad Institute · USMassachusetts General Hospital · USStanford University · USUniversity of California, San Francisco · USIndiana University School of MedicineMassachusetts Institute of Technology · USUniversity of Colorado Anschutz Medical Campus · US
Funding
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5MVector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Alejandro Antonio Pezzulo · 1998 to 2026
$30.5MPathology CoreP01HL152960 · NHLBI · UNIVERSITY OF IOWA · PI ENGELHARDT, JOHN F · 2020 to 2024
$11.6MBiology of Submucosal Gland Stem Cells in the AirwayR01HL165404 · NHLBI · UNIVERSITY OF IOWA · PI ENGELHARDT, JOHN F · 2022 to 2025
$2.9MNHLBI NIH HHS P01 HL152960NHLBI NIH HHS R01 HL165404NIDDK NIH HHS P30 DK054759
Abstract
Speciation leads to adaptive changes in organ cellular physiology and creates challenges for studying rare cell-type functions that diverge between humans and mice. Rare cystic fibrosis transmembrane conductance regulator (CFTR)-rich pulmonary ionocytes exist throughout the cartilaginous airways of humans
Indexed as
Cystic FibrosisDisease Models, AnimalFerretsLungTransgenesAnimalsAnimals, Genetically ModifiedCell LineageCystic Fibrosis Transmembrane Conductance RegulatorForkhead Transcription FactorsHumansTracheaCystic Fibrosis Transmembrane Conductance RegulatorForkhead Transcription Factors
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.