ArticleArchives of medical science : AMS2023
The association between frailty and osteoarthritis based on the NHANES and Mendelian randomization study.
Article in Archives of medical science : AMS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Immunological Insights into the Causal Link Between Arthritis, Osteoarthritis, and Frailty: An Integrated Analytical Study.International journal of medical sciences · 2025Pooled it
- A compendium of circulating biomarkers of senescence in humans: Insights on mechanistic impact across health domains and modulation by therapeutic interventions.Ageing research reviews · 2026Review
- Cross-Tissue Transcriptomic Convergence Identifies a Leuko-Cyte-Shared, Myeloid-Enriched Inflammatory Program in Frailty and Osteoarthritis.International journal of molecular sciences · 2026Article
- Association of the combined atherosclerosis index of plasma and frailty index with arthritis in middle-aged and older adults: a cohort study.Scientific reports · 2026Article
- Longitudinal association of frailty levels with knee osteoarthritis in middle-aged and elderly chinese: a longitudinal cohort study.Scientific reports · 2026Article
- The association between frailty and headache in middle-aged and older individuals: a data analysis based on the GBD2021, the CHARLS and Mendelian randomization.Archives of medical science : AMS · 2026Article
- Associations Between Longitudinal Changes in Frailty and Incident Arthritis: A Multi-Cohort Study.Risk management and healthcare policy · 2026Article
- Circulating microRNAs miR-21-5p, miR-23a-3p and miR-26a-5p reflect clinical and molecular features of aging.Scientific reports · 2025Article
- Disease clusters and death trajectories in individuals with frailty: a prospective cohort study from the UK Biobank.BMC public health · 2025Article
- Arthritis increases the risk of prostate cancer: Results from the National Health and Nutrition Examination Survey 2005-2018 and two-sample Mendelian randomization analysis.Investigative and clinical urology · 2025Article
- Shared genetic architecture and causal relationship between frailty and schizophrenia.Schizophrenia (Heidelberg, Germany) · 2025Article
- Mendelian randomization identifies the characteristic plasma metabolite profile of meningioma.Archives of medical science : AMS · 2025Article
- Whole-body water mass and osteoarthritis: a Mendelian randomization study.Archives of medical science : AMS · 2025Article
- A multi-stage genomic approach to uncover druggable gene targets and neural pathways in postpartum depression.Archives of medical science : AMS · 2025Article
- The genetic causal association between hip or knee osteoarthritis and frailty: a two-sample Mendelian randomization analysis.Archives of medical science : AMS · 2024Article
- Investigating the shared genetic architecture of osteoarthritis and frailty: a genome-wide cross-trait analysis.American journal of nuclear medicine and molecular imaging · 2024Article
- The effect of cheese intake on osteoarthritis: a Mendelian randomization study.Archives of medical science : AMS · 2024Article
- Association between added sugars and frailty in U.S. adults: a cross-sectional study from the National Health and Nutrition Examination Survey 2007-2018.Frontiers in public health · 2024Article
- Association of two novel systemic inflammatory biomarkers and frailty based on NHANES 2007-2018.Frontiers in public health · 2024Article
- Vitamin C intake and osteoarthritis: findings of NHANES 2003-2018 and Mendelian randomization study.Frontiers in nutrition · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The aim of the study was to examine the association between frailty and osteoarthritis. Methods: We conducted a cross-sectional study in the National Health and Nutrition Examination Survey, while logistic regression was used to explore the association of the two. Mendelian randomization (MR) study was used to explore the causal relationship between the two. Results: In the cross-sectional study, logistic regression analysis showed that odds ratio (OR) (95% CI) value was 1.07 (1.05, 1.08). In the MR study, the inverse-variance weighting (IVW) results showed OR (95% CI) value of 1.69 (1.01-2.83). Conclusions: There is both a correlation and a causal relationship between frailty and osteoarthritis, and frailty may be a potentially better response than age to osteoarthritis.
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Registered trials
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