Evidence map›Paper›PMID 37732207›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Extracellular Matrix Abnormalities in the Hippocampus of Subjects with Substance Use Disorder.

Jake Valeri, Charlotte Stiplosek, Sinead M O'Donovan, David Sinclair, Kathleen Grant, Ratna Bollavarapu, Donna M Platt, Craig A Stockmeier, Barbara Gisabella, Harry Pantazopoulos

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jake ValeriDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS.
Charlotte StiplosekDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS.
Sinead M O'DonovanDepartment of Neuroscience, University of Toledo, Toledo, OH.
David SinclairDepartment of Neuroscience, University of Toledo, Toledo, OH.
Kathleen GrantOregon Primate Research Center, Hillsboro, OR.
Ratna BollavarapuProgram in Neuroscience, University of Mississippi Medical Center, Jackson, MS.
Donna M PlattDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS.
Craig A StockmeierDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS.
Barbara GisabellaDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS.
Harry PantazopoulosDepartment of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS.
University of Mississippi Medical Center · USUniversity of Toledo · USOregon National Primate Research Center · US

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
Training and Mentoring Core P20GM103476 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI Jennifer L Lemacks · 2012 to 2026
$60.2M
Center for Psychiatric NeuroscienceP30GM103328 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI STOCKMEIER, CRAIG ALLEN · 2013 to 2017
$5.5M
GABA-A receptor subtype mechanisms and the abuse-related effects of alcoholR01AA029023 · NIAAA · UNIVERSITY OF MISSISSIPPI MED CTR · PI PLATT, DONNA M · 2020 to 2024
$2.4M
Diurnal Molecular Rhythms of the Human Hypothalamus and Involvement in Bipolar DisorderR01MH125833 · NIMH · UNIVERSITY OF MISSISSIPPI MED CTR · PI PANTAZOPOULOS, HARRY · 2021 to 2024
$1.6M
Morphological Correlates of Memory Consolidation During SleepR21MH117460 · NIMH · UNIVERSITY OF MISSISSIPPI MED CTR · PI GISABELLA, BARBARA · 2019 to 2020
$441k
Validation of the Regulatory Potential of Tailed MirtronsR15GM120716 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI FLYNT, ALEX · 2016 to 2016
$437k
The Role of the Extracellular Matrix in Alcohol Use DisorderF31AA030166 · NIAAA · UNIVERSITY OF MISSISSIPPI MED CTR · PI VALERI, JAKE RYAN · 2023 to 2024
$57k
NIAAA NIH HHS F31 AA030166NIAAA NIH HHS R01 AA029023NIGMS NIH HHS P20 GM103476NIGMS NIH HHS P30 GM103328NIGMS NIH HHS R15 GM120716NIH HHS P51 OD011092NIMH NIH HHS R01 MH125833NIMH NIH HHS R21 MH117460
6 · The paper itself

Abstract

Contextual triggers are significant factors contributing to relapse in substance use disorders (SUD). Emerging evidence points to a critical role of extracellular matrix (ECM) molecules as mediators of reward memories. Chondroitin sulfate proteoglycans (CSPGs) are a subset of ECM molecules that form perineuronal nets (PNN) around inhibitory neurons. PNNs restrict synaptic connections and help maintain synapses. Rodent models suggest that modulation of PNNs may strengthen contextual reward memories in SUD. However, there is currently a lack of information regarding PNNs in the hippocampus of people with SUD as well as how comorbidity with major depressive disorder (MDD) may affect PNNs. We used postmortem hippocampal tissues from cohorts of human and nonhuman primates with or without chronic alcohol use to test the hypothesis that PNNs are increased in subjects with SUD. We used histochemical labeling and quantitative microscopy to examine PNNs, and qRT-PCR to examine gene expression for ECM molecules, synaptic markers and related markers. We identified increased densities of PNNs and CSPG-labeled glial cells in SUD, coinciding with decreased expression of the ECM protease matrix metalloproteinase 9 (

Identifiers

PMID37732207
PMCPMC10508799
OpenAlexW4386533473

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.