Evidence map›Paper›PMID 37734036›Full record

ArticleAmerican journal of respiratory cell and molecular biology2024

Prenatal FGFR2 Signaling via PI3K/AKT Specifies the PDGFRA

Matthew R Riccetti, Jenna Green, Thomas J Taylor, Anne-Karina T Perl

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Matthew R RiccettiDivision of Neonatology and Pulmonary Biology and.ORCID 0000-0001-6514-0862
Jenna GreenDivision of Neonatology and Pulmonary Biology and.
Thomas J TaylorDivision of Neonatology and Pulmonary Biology and.
Anne-Karina T PerlDivision of Neonatology and Pulmonary Biology and.ORCID 0000-0002-8445-4565
Cincinnati Children's Hospital Medical Center · US

Funding

Editing Alveolar Progenitor Cells for Correction of Monogenic DiseaseU01HL134745 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI KOTTON, DARRELL N., MORRISEY, EDWARD E · 2016 to 2022
$8.3M
Molecular Atlas of Lung Development - Data Coordinating CenterU01HL122638 · NHLBI · DUKE UNIVERSITY · PI CLARK, ROBERT F, PALMER, SCOTT M · 2014 to 2018
$7.5M
Pulmonary Development and Disease Pathogenesis Training ProgramT32HL007752 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Francis Xavier McCormack, Anne-Karina Theresia Perl · 1994 to 2026
$6.3M
"Lung MAP" Atlas Research CenterU01HL122642 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI POTTER, S. STEVEN, WHITSETT, JEFFREY A · 2014 to 2018
$3.9M
Role of alveolar fibroblasts in extracellular matrix organization and alveolar type 1 cell differentiationR01HL167030 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Anne-Karina Theresia Perl · 2023 to 2026
$3.1M
Interstitial resident fibroblasts direct alveolar epithelial differentiationR01HL131661 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI PERL, ANNE-KARINA THERESIA · 2017 to 2020
$1.9M
FGF and PDGF regulate myofibroblast differentiation in alveolar regenerationR01HL104003 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI PERL, ANNE-KARINA THERESIA · 2010 to 2013
$1.5M
The role of transcription factor MEOX2 in lipofibroblast function during alveolarizationF31HL162470 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI RICCETTI, MATTHEW · 2022 to 2023
$73k
NHLBI NIH HHS F31 HL162470NHLBI NIH HHS R01 HL104003NHLBI NIH HHS R01 HL131661NHLBI NIH HHS R01 HL167030NHLBI NIH HHS T32 HL007752NHLBI NIH HHS U01 HL122638NHLBI NIH HHS U01 HL122642NHLBI NIH HHS U01 HL134745
6 · The paper itself

Abstract

It is well known that FGFR2 (fibroblast growth factor receptor 2) signaling is critical for proper lung development. Recent studies demonstrate that epithelial FGFR2 signaling during the saccular phase of lung development (sacculation) regulates alveolar type 1 (AT1) and AT2 cell differentiation. During sacculation, PDGFRA (platelet-derived growth factor receptor-α)-positive lung fibroblasts exist as three functional subtypes: contractile myofibroblasts, extracellular matrix-producing matrix fibroblasts, and lipofibroblasts. All three subtypes are required during alveolarization to establish a niche that supports AT2 epithelial cell self-renewal and AT1 epithelial cell differentiation. FGFR2 signaling directs myofibroblast differentiation in PDGFRA

Indexed as

MyofibroblastsReceptor, Fibroblast Growth Factor, Type 2Cell DifferentiationCells, CulturedFibroblastsLungPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktReceptor, Fibroblast Growth Factor, Type 2alveolar nichelipofibroblastlung developmentmatrix fibroblastsacculation

Identifiers

PMID37734036
PMCPMC10768833
OpenAlexW4386915548

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.