Evidence map›Paper›PMID 37734757›Full record

SynthesisBMJ (Clinical research ed.)2023

Suboptimal gestational weight gain and neonatal outcomes in low and middle income countries: individual participant data meta-analysis.

Nandita Perumal, Dongqing Wang, Anne Marie Darling, Enju Liu, Molin Wang, Tahmeed Ahmed, Parul Christian, Kathryn G Dewey, Gilberto Kac, Stephen H Kennedy and 4 more

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ (Clinical research ed.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  14. Predictive Factors for Small Head Circumference Among Pregnant Women with Third-Trimester Anemia.International journal of environmental research and public health · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nandita PerumalDepartment of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA.ORCID 0000-0003-3624-4405
Dongqing WangDepartment of Global and Community Health, College of Health and Human Services, George Mason University, Fairfax, VA, USA.
Anne Marie DarlingDepartment of Global Health and Population, Harvard T H Chan School of Public Health, Harvard University, Boston, MA, USA.
Enju LiuInstitutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, MA, USA.
Molin WangDepartment of Epidemiology, Harvard T H Chan School of Public Health, Harvard University, Boston, MA, USA.
Tahmeed AhmedNutrition & Clinical Services, International Centre for Diarrheal Disease Research, Dhaka, Bangladesh.
Parul ChristianDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Kathryn G DeweyDepartment of Nutrition, University of California, Davis, CA, USA.
Gilberto KacNutritional Epidemiology Observatory, Josué de Castro Nutrition Institute, Rio de Janeiro Federal University, Rio de Janeiro, Brazil.
Stephen H KennedyNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.
Vishak SubramoneyDVPL Tech, Dubai, United Arab Emirates.
Brittany BriggsCertara USA, on behalf of the Bill & Melinda Gates Foundation, Seattle, WA, USA.
Wafaie W FawziDepartment of Global Health and Population, Harvard T H Chan School of Public Health, Harvard University, Boston, MA, USA.
GWG Pooling Project Consortium

Funding

Nutrition-specific interventions to improve long-term maternal-child health outcomesUG1HD076474 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Edwin Jose Asturias, NANCY F KREBS · 2018 to 2026
$5.4M
NICHD NIH HHS UG1 HD076474
6 · The paper itself

Abstract

objectiveTo estimate the associations between gestational weight gain (GWG) during pregnancy and neonatal outcomes in low and middle income countries.

designIndividual participant data meta-analysis.

settingProspective pregnancy studies from 24 low and middle income countries.

main outcome measuresNine neonatal outcomes related to timing (preterm birth) and anthropometry (weight, length, and head circumference) at birth, stillbirths, and neonatal death. ANALYSIS

methodsA systematic search was conducted in PubMed, Embase, and Web of Science which identified 53 prospective pregnancy studies published after the year 2000 with data on GWG, timing and anthropometry at birth, and neonatal mortality. GWG adequacy was defined as the ratio of the observed maternal weight gain over the recommended weight gain based on the Institute of Medicine body mass index specific guidelines, which are derived from data in high income settings, and the INTERGROWTH-21st GWG standards. Study specific estimates, adjusted for confounders, were generated and then pooled using random effects meta-analysis models. Maternal age and body mass index before pregnancy were examined as potential modifiers of the associations between GWG adequacy and neonatal outcomes.

resultsOverall, 55% of participants had severely inadequate (<70%) or moderately inadequate (70% to <90%) GWG, 22% had adequate GWG (90-125%), and 23% had excessive GWG (≥125%). Severely inadequate GWG was associated with a higher risk of low birthweight (adjusted relative risk 1.62, 95% confidence interval 1.51 to 1.72; 48 studies, 93 337 participants; τ

conclusionsInadequate and excessive GWG are associated with a higher risk of adverse neonatal outcomes across settings. Interventions to promote optimal GWG during pregnancy are likely to reduce the burden of adverse neonatal outcomes, however further research is needed to assess optimal ranges of GWG based on data from low and middle income countries.

Indexed as

Gestational Weight GainPremature BirthDeveloping CountriesFemaleHumansInfant, NewbornPregnancyProspective StudiesUnited StatesWeight Gain

Identifiers

PMID37734757
PMCPMC10512803

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.