Evidence map›Paper›PMID 37735323›Full record

ArticleInternational journal of hematology2023

Clinical significance of human neutrophil antigen-1 antibodies in children with neutropenia.

Satoshi Goda, Shuhei Karakawa, Satoshi Okada, Hiroshi Kawaguchi, Emi Kurita, Mitsunori Noma, Aiko Yamaoka, Mayumi Komatsu, Ayaka Yanai, Mayu Kashihara and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in International journal of hematology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. New-onset aplastic anemia after SARS-CoV-2 vaccination.International journal of hematology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Satoshi Goda *Department of Pediatrics, Graduate School of Biomedical & Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-Ku, Hiroshima, Japan. satorunozitensya@gmail.com.ORCID http://orcid.org/0000-0003-0135-8701
Shuhei Karakawa *Department of Pediatrics, Graduate School of Biomedical & Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-Ku, Hiroshima, Japan.
Satoshi OkadaDepartment of Pediatrics, Graduate School of Biomedical & Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-Ku, Hiroshima, Japan.
Hiroshi KawaguchiDepartment of Pediatrics, Graduate School of Biomedical & Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-Ku, Hiroshima, Japan.
Emi KuritaDivision of Transfusion, Hiroshima University Hospital, Hiroshima University, Hiroshima, Japan.
Mitsunori NomaDivision of Transfusion, Hiroshima University Hospital, Hiroshima University, Hiroshima, Japan.
Aiko YamaokaDivision of Transfusion, Hiroshima University Hospital, Hiroshima University, Hiroshima, Japan.
Mayumi KomatsuDivision of Transfusion, Hiroshima University Hospital, Hiroshima University, Hiroshima, Japan.
Ayaka YanaiDivision of Transfusion, Hiroshima University Hospital, Hiroshima University, Hiroshima, Japan.
Mayu KashiharaDivision of Transfusion, Hiroshima University Hospital, Hiroshima University, Hiroshima, Japan.
Teruhisa FujiiDivision of Transfusion, Hiroshima University Hospital, Hiroshima University, Hiroshima, Japan.
Rie OnoderaDepartment of Medical Technology, Sanyo Women's College, Hatsukaichi, Japan.
Kikuyo TaniguchiDepartment of Medical Technology, Sanyo Women's College, Hatsukaichi, Japan.
Mika AizawaDepartment of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, Higashi-Hiroshima, Japan.
Masao KobayashiJapanese Red Cross Chugoku-Shikoku Block Blood Center, Hiroshima, Japan.
Hiroshima University Hospital · JPHiroshima University · JPSanyo Women's College · JPJapanese Red Cross Society, Japan · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary autoimmune neutropenia in young children is characterized by chronic neutropenia and positivity for antibodies against human neutrophil antigens (HNAs). This study analyzed the clinical characteristics of 402 children with neutropenia to identify differences between those with and without HNA-1 antibodies (HNA1abs). HNAabs in sera were detected by granulocyte immunofluorescence testing using flow cytometry. Relative fluorescence intensity (RFI) values were used to divide patients into positive (PG, n = 302), borderline (BG, n = 34), and negative (NG, n = 66) groups. The antibodies reacted to HNA-1a alone (59%), HNA-1b alone (1%), and HNA-1a/1b (40%). The PG had a significantly lower absolute neutrophil count before definitive diagnosis and a 1.6- to 2-times greater risk of hospitalization during neutropenia than the other groups. The median duration of neutropenia was longest in the PG at 25 months, followed by 20 months in the BG and 14 months in the NG. This large-scale cohort characterizes clinically distinct groups using the RFI value for HNA1abs in young children with neutropenia. Detection of HNA1abs may aid in understanding the clinical characteristics of children with neutropenia.

Indexed as

NeutropeniaNeutrophilsAutoantibodiesChildChild, PreschoolClinical RelevanceGranulocytesHumansIsoantigensAutoantibodiesIsoantigensAutoantibodyAutoimmune neutropeniaChildhoodHuman neutrophil antigen

Identifiers

PMID37735323
OpenAlexW4386923382

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.