ReviewGenes, brain, and behavior2023
The Collaborative Study on the Genetics of Alcoholism: Overview.
Review in Genes, brain, and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Lifespan Trajectories of Resting State EEG power.bioRxiv : the preprint server for biology · 2026Article
- Blood-Based Epigenetic Signatures in Brazilian Males With Alcohol Use Disorder.Addiction biology · 2026Article
- Alcohol use disorder is associated with altered frontomedial phase-amplitude coupling strength during resting state.Neuroimage. Reports · 2026Article
- Leveraging Machine Learning to Advance Alcohol Research: Current Applications, Challenges, and Opportunities.Alcohol research : current reviews · 2026Review
- The effects of marital status, partner drinking, and sex differences on the likelihood of remission from alcohol use disorder.Alcohol and alcoholism (Oxford, Oxfordshire) · 2025Article
- A Multivariate Genomic Investigation of the Externalizing Spectrum and Suicide Risk.medRxiv : the preprint server for health sciences · 2025Article
- Childhood Trauma andmedRxiv : the preprint server for health sciences · 2025Article
- Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations.Nature human behaviour · 2025Article
- Whole Genome Sequencing of Pedigrees With High Density of Substance Use and Psychiatric Disorders: A Meeting Report.Genes, brain, and behavior · 2025Article
- [Long-term courses of alcohol dependence].Der Nervenarzt · 2025Review
- Polygenic risk for alcohol use disorder affects cellular responses to ethanol exposure in a human microglial cell model.Science advances · 2024Article
- Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with an alcohol use disorder.medRxiv : the preprint server for health sciences · 2024Article
- Another Swim in the Extensive Pool of Zebrafish Research.Biomedicines · 2024Article
- Diagnostic Criteria for Identifying Individuals at High Risk of Progression From Mild or Moderate to Severe Alcohol Use Disorder.JAMA network open · 2023Article
- The Collaborative Study on the Genetics of Alcoholism: Overview.Genes, brain, and behavior · 2023Review
- Collaborative study on the genetics of alcoholism: The strength of collaboration, team science, and longitudinal data.Genes, brain, and behavior · 2023Article
- Clinical, Genomic, and Neurophysiological Correlates of Lifetime Suicide Attempts among Individuals with an Alcohol Use Disorder.Complex psychiatryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 8 institutions in 1 country.
Funding
Abstract
Alcohol use disorders (AUD) are commonly occurring, heritable and polygenic disorders with etiological origins in the brain and the environment. To outline the causes and consequences of alcohol-related milestones, including AUD, and their related psychiatric comorbidities, the Collaborative Study on the Genetics of Alcoholism (COGA) was launched in 1989 with a gene-brain-behavior framework. COGA is a family based, diverse (~25% self-identified African American, ~52% female) sample, including data on 17,878 individuals, ages 7-97 years, in 2246 families of which a proportion are densely affected for AUD. All participants responded to questionnaires (e.g., personality) and the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) which gathers information on psychiatric diagnoses, conditions and related behaviors (e.g., parental monitoring). In addition, 9871 individuals have brain function data from electroencephalogram (EEG) recordings while 12,009 individuals have been genotyped on genome-wide association study (GWAS) arrays. A series of functional genomics studies examine the specific cellular and molecular mechanisms underlying AUD. This overview provides the framework for the development of COGA as a scientific resource in the past three decades, with individual reviews providing in-depth descriptions of data on and discoveries from behavioral and clinical, brain function, genetic and functional genomics data. The value of COGA also resides in its data sharing policies, its efforts to communicate scientific findings to the broader community via a project website and its potential to nurture early career investigators and to generate independent research that has broadened the impact of gene-brain-behavior research into AUD.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.