Evidence map›Paper›PMID 37736873›Full record

ArticleESC heart failure2023

Genetically predicted androgenic profiles and adverse cardiac markers: a sex-specific Mendelian randomization study.

Jun Yu Chen, Maddalena Ardissino, Rohin K Reddy, Amy Marie Mason, Zahra Raisi-Estabragh, Emanuele Di Angelantonio, Stephen Burgess, Fu Siong Ng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Jun Yu ChenNational Heart and Lung Institute, Imperial College London, London, UK.ORCID 0000-0002-1823-8282
Maddalena ArdissinoNational Heart and Lung Institute, Imperial College London, London, UK.
Rohin K ReddyNational Heart and Lung Institute, Imperial College London, London, UK.
Amy Marie MasonBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Zahra Raisi-EstabraghWilliam Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK.
Emanuele Di AngelantonioBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Stephen BurgessBritish Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Fu Siong NgNational Heart and Lung Institute, Imperial College London, London, UK.
University of Cambridge · GBLung Institute · USSt Bartholomew's Hospital · GB

Funding

British Heart Foundation RG/13/13/30194British Heart Foundation RG/16/3/32175British Heart Foundation RG/18/13/33946Medical Research Council MC_UU_00002/7Wellcome Trust 100114
6 · The paper itself

Abstract

aimsObservational evidence suggests associations between sex hormone levels and heart failure (HF). We used sex-specific genetic variants associated with androgenic sex hormone profiles to investigate the causal relevance of androgenic sex hormone profiles on cardiac structure and function and HF using Mendelian randomization (MR). METHODS AND

resultsSex-specific uncorrelated genome-wide significant (P < 5 × 10

conclusionsThis study supports a causal effect of pro-androgenic sex hormone profiles in females on adverse markers of left ventricular structure and function typically associated with HF with preserved ejection fraction and with HF. There was weaker evidence of association in males.

Indexed as

AndrogensHeart FailureFemaleGenome-Wide Association StudyGonadal Steroid HormonesHumansMaleMendelian Randomization AnalysisStroke VolumeTestosteroneVentricular Function, LeftAndrogensGonadal Steroid HormonesTestosteroneCMRHeart failureMendelian randomizationSex hormonesSHBGTestosterone

Identifiers

PMID37736873
PMCPMC10682908
OpenAlexW4386944869

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.