Evidence map›Paper›PMID 37736935›Full record

ArticleClinics and practice2023

Pleural Fluid-to-Blood BNP Ratio May Contribute to Prognosis in Malignant Pleural Mesothelioma.

Vasiliki Tsolaki, George E Zakynthinos, Sotirios Zarogiannis, Paris Zygoulis, Ioannis Kalomenidis, Rajesh Jagirdar, Ioannis Triantafyllou, Konstantinos I Gourgoulianis, Demosthenes Makris, Epaminondas Zakynthinos

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinics and practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 66% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Vasiliki TsolakiIntensive Care Unit, Faculty of Medicine, University of Thessaly, University Hospital of Larissa, 41335 Larissa, Greece.ORCID 0000-0003-2412-5388
George E ZakynthinosThird Cardiology Clinic, University of Athens, Sotiria Hospital, 11527 Athens, Greece.ORCID 0000-0003-4444-0967
Sotirios ZarogiannisDepartment of Physiology, Faculty of Medicine, University of Thessaly, 41500 Larissa, Greece.ORCID 0000-0002-3083-3244
Paris ZygoulisIntensive Care Unit, Faculty of Medicine, University of Thessaly, University Hospital of Larissa, 41335 Larissa, Greece.
Ioannis Kalomenidis1st Department of Critical Care and Pulmonary Medicine, National and Kapodistrian University of Athens, 10676 Athens, Greece.
Rajesh JagirdarDepartment of Physiology, Faculty of Medicine, University of Thessaly, 41500 Larissa, Greece.
Ioannis TriantafyllouDepartment of Computer Science and Biomedical Informatics, School of Sciences, University of Thessaly, 35131 Lamia, Greece.ORCID 0000-0002-7512-5217
Konstantinos I GourgoulianisRespiratory Medicine Department, Faculty of Medicine, University of Thessaly, University Hospital of Larisa, 41335 Larissa, Greece.ORCID 0000-0001-9541-1010
Demosthenes MakrisIntensive Care Unit, Faculty of Medicine, University of Thessaly, University Hospital of Larissa, 41335 Larissa, Greece.
Epaminondas ZakynthinosIntensive Care Unit, Faculty of Medicine, University of Thessaly, University Hospital of Larissa, 41335 Larissa, Greece.
University of Thessaly · GRNational and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBrain natriuretic peptide (BNP) seems to be produced from malignant mesothelial cells other than cardiomyocytes. We aimed to evaluate whether an increased pleural fluid-to-blood BNP ratio in patients with malignant pleural mesothelioma (MPM) could facilitate prognosis beyond diagnosis. MATERIALS AND

methodsPatients with MPM were included (observational study). One- and two-year survival and factors affecting it were tested. To evaluate the prognostic significance of the natriuretic peptide precursor B (NPPB) gene expression in MPM, we constructed a survival curve from data derived from The Cancer Genome Atlas.

resultsNineteen consecutive patients with MPM were included (age: 67 (61, 80), male 78.9%). One- and two-year survival were 52.6% and 31.6%, respectively. Age, performance status, and the other variables tested did not differ between survivors and non-survivors. Non-survivors presented higher pleural fluid BNP in two years (699 (210, 5000) vs. 379.5 (5, 567),

conclusionA high pleural fluid/blood BNP ratio, an easily performed in everyday practice, costless biomarker seems to predict poorer survival better than the commonly reported prognostic factors in MPM.

Indexed as

brain natriuretic peptidemalignant pleural mesotheliomaprognosissurvival

Identifiers

PMID37736935
PMCPMC10514826
OpenAlexW4386741721

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.