ArticleThe Plant cell2023
A CYP78As-small grain4-coat protein complex Ⅱ pathway promotes grain size in rice.
Article in The Plant cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 30 citations in OpenAlex.
- Identification of stable QTL for yield-related traits in a durum wheat Svevo × Zavitan RIL population.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- OsVPS34-generated PI3P recruits GPA5/Rab5a to regulate post-Golgi glutelin trafficking in rice endosperm.Plant physiology · 2026Article
- Overexpression of the BAHD Acyltransferase-Like Protein gene OsDCR Enhances Salt Tolerance in Rice.Rice (New York, N.Y.) · 2026Article
- OsMATE16 Regulates Anther Dehiscence by Modulating IAA Content Under High Temperature.Rice (New York, N.Y.) · 2026Article
- The mysterious dialogue between the embryo, endosperm, and seed coat, and its implications for seed traits.Journal of experimental botany · 2026Review
- Interaction with COPII Member SAR1 Is Critical for the Delivery ofPlants (Basel, Switzerland) · 2026Article
- Natural variation in Phosphatidylinositol 4-Kinase OsPI4Kγ7 and its interaction with OsLIC balance rice yield and latitudinal adaptation.Nature communications · 2026Article
- GmCDC7 is involved in coordinating seed size and quality in soybean.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- The OsbZIP35-COR1-OsTCP19 module modulates cell proliferation to regulate grain length and weight in rice.Science advances · 2025Article
- Tiny seeds, big decisions: Jasmonate-mediated regulation of seed size in Arabidopsis via the SOD7-KLU module.The Plant cell · 2025Article
- NAC Transcription FactorPlants (Basel, Switzerland) · 2025Article
- Telomere-to-telomere gap-free genome assembly provides genetic insight into the triterpenoid saponins biosynthesis inHorticulture research · 2025Article
- Genome-Wide Identification of thePlants (Basel, Switzerland) · 2025Article
- The OsZHD1 and OsZHD2, Two Zinc Finger Homeobox Transcription Factor, Redundantly Control Grain Size by Influencing Cell Proliferation in Rice.Rice (New York, N.Y.) · 2025Article
- Gene Pyramiding Strategies for Sink Size and Source Capacity for High-Yield Japonica Rice Breeding.Rice (New York, N.Y.) · 2025Review
- Article
- Cytochromes P450 evolution in the plant terrestrialization context.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Pleiotropic phenotypic effects of the TaCYP78A family on multiple yield-related traits in wheat.Plant biotechnology journal · 2024Article
- Genome-Wide Association Analysis of Yield-Related Traits and Candidate Genes in Vegetable Soybean.Plants (Basel, Switzerland) · 2024Article
- Article
Corrections and comments
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Authors and funding
26 authors at 2 institutions in 1 country.
Funding
Abstract
CYP78A, a cytochrome P450 subfamily that includes rice (Oryza sativa L.) BIG GRAIN2 (BG2, CYP78A13) and Arabidopsis thaliana KLUH (KLU, CYP78A5), generate an unknown mobile growth signal (referred to as a CYP78A-derived signal) that increases grain (seed) size. However, the mechanism by which the CYP78A pathway increases grain size remains elusive. Here, we characterized a rice small grain mutant, small grain4 (smg4), with smaller grains than its wild type due to restricted cell expansion and cell proliferation in spikelet hulls. SMG4 encodes a multidrug and toxic compound extrusion (MATE) transporter. Loss of function of SMG4 causes smaller grains while overexpressing SMG4 results in larger grains. SMG4 is mainly localized to endoplasmic reticulum (ER) exit sites (ERESs) and partially localized to the ER and Golgi. Biochemically, SMG4 interacts with coat protein complex Ⅱ (COPⅡ) components (Sar1, Sec23, and Sec24) and CYP78As (BG2, GRAIN LENGTH 3.2 [GL3.2], and BG2-LIKE 1 [BG2L1]). Genetically, SMG4 acts, at least in part, in a common pathway with Sar1 and CYP78As to regulate grain size. In summary, our findings reveal a CYP78As-SMG4-COPⅡ regulatory pathway for grain size in rice, thus providing new insights into the molecular and genetic regulatory mechanism of grain size.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.