Evidence map›Paper›PMID 37745422›Full record

ArticlebioRxiv : the preprint server for biology2023

Magnetically Powered Microwheel Thrombolysis of Occlusive Thrombi in Zebrafish.

M Hao Hao Pontius, Chia-Jui Ku, Matthew Osmond, Dante Disharoon, Yang Liu, David W M Marr, Keith B Neeves, Jordan A Shavit

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

M Hao Hao PontiusDepartment of Pediatrics, University of Michigan, Ann Arbor, MI.
Chia-Jui KuDepartment of Pediatrics, University of Michigan, Ann Arbor, MI.
Matthew OsmondDepartment of Chemical and Biological Engineering, Colorado School of Mines, Golden, CO.
Dante DisharoonDepartment of Chemical and Biological Engineering, Colorado School of Mines, Golden, CO.
Yang LiuDepartment of Pediatrics, University of Michigan, Ann Arbor, MI.
David W M MarrDepartment of Chemical and Biological Engineering, Colorado School of Mines, Golden, CO.
Keith B NeevesDepartments of Bioengineering and Pediatrics, University of Colorado, Denver | Anschutz Medical Campus, Aurora, CO.
Jordan A ShavitDepartment of Pediatrics, University of Michigan, Ann Arbor, MI.
University of Michigan · USColorado School of Mines · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Genetic and therapeutic studies of hemostatic and thrombotic disorders using zebrafishR35HL150784 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jordan A. Shavit · 2020 to 2026
$5.4M
Magnetically propelled microwheels for rapid thrombolysis in small arteriesR01NS102465 · NINDS · COLORADO SCHOOL OF MINES · PI MARR, DAVID WM, NEEVES, KEITH B · 2018 to 2022
$2.6M
NHLBI NIH HHS R35 HL150784NINDS NIH HHS R01 NS102465
6 · The paper itself

Abstract

Tissue plasminogen activator (tPA) is the only FDA approved treatment for ischemic stroke but carries significant risks, including major hemorrhage. Additional options are needed, especially in small vessel thrombi which account for ~25% of ischemic strokes. We have previously shown that tPA-functionalized colloidal microparticles can be assembled into microwheels (µwheels) and manipulated under the control of applied magnetic fields to enable rapid thrombolysis of fibrin gels in microfluidic models of thrombosis. Providing a living microfluidic analog, transparent zebrafish larvae have a highly conserved coagulation cascade that enables studies of hemostasis and thrombosis in the context of intact vasculature, clotting factors, and blood cells. Here we show that tPA-functionalized µwheels can perform rapid and targeted recanalization

Identifiers

PMID37745422
PMCPMC10515822
OpenAlexW4386767581

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.