Evidence map›Paper›PMID 37745434›Full record

ArticlebioRxiv : the preprint server for biology2023

Global brain activity and its coupling with cerebrospinal fluid flow is related to tau pathology.

Feng Han, JiaQie Lee, Xi Chen, Jacob Ziontz, Tyler Ward, Susan M Landau, Suzanne L Baker, Theresa M Harrison, William J Jagust

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Feng HanHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.
JiaQie LeeHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.
Xi ChenHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.
Jacob ZiontzHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.
Tyler WardHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.
Susan M LandauHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.
Suzanne L BakerLawrence Berkeley National Laboratory, Berkeley, CA, USA.
Theresa M HarrisonHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.
William J JagustHelen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA, USA.
University of California, Berkeley · USLawrence Berkeley National Laboratory · US

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MONICA G. RIVERA-MINDT · 2016 to 2026
$226.7M
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Linking basal forebrain and entorhinal cortex vulnerability to preclinical Alzheimer's diseaseK01AG078443 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI Theresa M. Harrison · 2022 to 2026
$656k
Functional networks underlying cognitive decline in aging and Alzheimer's diseaseF31AG079595 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI ZIONTZ, JACOB · 2022 to 2023
$86k
NIA NIH HHS F31 AG079595NIA NIH HHS K01 AG078443NIA NIH HHS U01 AG024904NIA NIH HHS U19 AG024904
6 · The paper itself

Abstract

Amyloid-β (Aβ) and tau deposition constitute Alzheimer's disease (AD) neuropathology. Cortical tau deposits first in the entorhinal cortex and hippocampus and then propagates to neocortex in an Aβ-dependent manner. Tau also tends to accumulate earlier in higher-order association cortex than in lower-order primary sensory-motor cortex. While previous research has examined the production and spread of tau, little attention has been paid to its clearance. Low-frequency (<0.1 Hz) global brain activity during the resting state is coupled with cerebrospinal fluid (CSF) flow and potentially reflects glymphatic clearance. Here we report that tau deposition in subjects with evaluated Aβ, accompanied by cortical thinning and cognitive decline, is strongly associated with decreased coupling between CSF flow and global brain activity. Substantial modulation of global brain activity is also manifested as propagating waves of brain activation between higher- and lower-order regions, resembling tau spreading. Together, the findings suggest an important role of resting-state global brain activity in AD tau pathology.

Indexed as

cerebrospinal fluid flowglobal resting-state fMRI signalglymphatic systemhigh-order association regionspropagating wave of brain activity, Alzheimer’s disease pathologytau deposition

Identifiers

PMID37745434
PMCPMC10515801
OpenAlexW4386699925

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.