Evidence map›Paper›PMID 37745459›Full record

ArticlebioRxiv : the preprint server for biology2023

Rab35 is required for embryonic development and kidney and ureter homeostasis through regulation of epithelial cell junctions.

Kelsey R Clearman, Napassawon Timpratoom, Dharti Patel, Addison B Rains, Courtney J Haycraft, Mandy J Croyle, Jeremy F Reiter, Bradley K Yoder

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Kelsey R ClearmanDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, United States.
Napassawon TimpratoomDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, United States.
Dharti PatelDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, United States.
Addison B RainsDepartment of Craniofacial Biology at the University of Colorado Anschutz Medical Campus, Denver, Co, United States.
Courtney J HaycraftDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, United States.
Mandy J CroyleDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, United States.
Jeremy F ReiterDepartment of Biochemistry and Biophysics, University of California at San Francisco, San Francisco, CA, United States.
Bradley K YoderDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, United States.
University of Alabama at Birmingham · USUniversity of California, San Francisco · USUniversity of Colorado Anschutz Medical Campus · US

Funding

ZINC DIETARY ALTERATIONS OF CADMIUM INDUCED HEPATIC TOXICITY IN RATSS06GM008111 · NIGMS · FLORIDA AGRICULTURAL AND MECHANICAL UNIV · PI REAMS, ROMONIA RENEE · 1989 to 2008
$9.1M
Training Program in Cell, Molecular, and Developmental BiologyT32GM008111 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI YODER, BRADLEY K. · 1985 to 2022
$5.4M
Understanding Ciliary Functions in Mammalian DevelopmentR01HD089918 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI REITER, JEREMY F, YODER, BRADLEY K. · 2017 to 2021
$3.0M
PRedoctoral Interdisciplinary training in renal physiology and MEdicine (PRIME)T32DK116672 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI POLLOCK, JENNIFER S · 2018 to 2022
$761k
NICHD NIH HHS R01 HD089918NIDDK NIH HHS T32 DK116672NIGMS NIH HHS S06 GM008111NIGMS NIH HHS T32 GM008111
6 · The paper itself

Abstract

Background: Rab35 is a member of a GTPase family of endocytic trafficking proteins. Studies in cell lines have indicated that Rab35 participates in cell adhesion, polarity, cytokinesis, and primary cilia length and composition. Additionally, sea urchin Rab35 regulates actin organization and is required for gastrulation. In mice, loss of Rab35 in the CNS disrupts hippocampal development and neuronal organization. Outside of the CNS, the functions of mammalian Rab35 Methods: We generated and analyzed the consequences of both congenital and conditional null Results: Congenital Conclusion: Rab35 is essential for mammalian development and the maintenance of kidney and ureter architecture. Loss of Rab35 leads to non-obstructive hydronephrosis, making the

Identifiers

PMID37745459
PMCPMC10515836
OpenAlexW4386688533

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.