ArticlebioRxiv : the preprint server for biology2024
A brown fat-enriched adipokine, ASRA, is a leptin receptor antagonist that stimulates appetite.
Lei Huang, Pengpeng Liu, Yong Du, J Fernando Bazan, Dongning Pan, Qingbo Chen, Alexandra Lee, Vijaya Sudhakara Rao Kola, Scot A Wolfe, Yong-Xu Wang
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors at 3 institutions in 3 countries.
Lei HuangDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Pengpeng LiuDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Yong DuDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
J Fernando BazanBioconsulting llc, Stillwater, MN, USA.
Dongning PanDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Qingbo ChenDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Alexandra LeeProgram in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Vijaya Sudhakara Rao KolaDepartment of Medicine and Division of Hematology/Oncology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Scot A WolfeDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-7042-201X Yong-Xu WangDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-0852-4787 University of Massachusetts Chan Medical School · USShanghai Medical College of Fudan University · CNSimulConsult · US
Funding
Rectifying splicing mutations in blood disorders by gene editingR01HL150669 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI BAUER, DANIEL EVAN, WOLFE, SCOT A · 2020 to 2023
$3.5MEnhancing CRISPR Gene Editing in Somatic Tissues by Chemical Modification of Guides and DonorsUH3TR002668 · NCATS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KHVOROVA, ANASTASIA, SONTHEIMER, ERIK J. · 2021 to 2022
$3.1MA novel adipokine suppresses leptin signaling and promotes obesityR01DK116872 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WANG, YONG-XU · 2019 to 2022
$1.7MRegulation of white fat browning by a novel, brown fat-secreted adipokineR01DK115918 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI WANG, YONG-XU · 2018 to 2020
$1.3MNCATS NIH HHS UH3 TR002668NHLBI NIH HHS R01 HL150669NIDDK NIH HHS R01 DK115918NIDDK NIH HHS R01 DK116872
6 · The paper itselfAbstract
The endocrine control of food intake remains incompletely understood, and whether the leptin receptor (LepR)-mediated anorexigenic pathway in the hypothalamus is negatively regulated by a humoral factor is unknown. Here, we identify an appetite-stimulating factor - ASRA - that represents a peripheral signal of energy deficit and orthosterically antagonizes LepR signaling.
Identifiers
PMID37745491
PMCPMC10515849
OpenAlexW4386714941
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390