Evidence map›Paper›PMID 37747188›Full record

ArticlemSphere2023

The antihelminth drug rafoxanide reverses chromosomal-mediated colistin-resistance in

Rongjia Han, Jiabao Xing, Huarun Sun, Zeyu Guo, Kaifang Yi, Gongzheng Hu, Yajun Zhai, Tony Velkov, Hua Wu

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Disruption ofVirulence · 2026
    Article
  2. Repurposing loratadine to reverse colistin resistance inEmerging microbes & infections · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Rongjia Han *Department of Pharmacology and Toxicology, College of Veterinary Medicine, Henan Agricultural University , Zhengzhou, China.
Jiabao Xing *Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, College of Veterinary Medicine, South China Agricultural University , Guangzhou, China.ORCID 0000-0002-1212-265X
Huarun SunCollege of Animal Science and Veterinary Medicine, Henan Institute of Science and Technology , Xinxiang, China.
Zeyu GuoNational Reference Laboratory of Veterinary Drug Residues (SCAU), College of Veterinary Medicine, South China Agricultural University , Guangzhou, China.
Kaifang YiDepartment of Pharmacology and Toxicology, College of Veterinary Medicine, Henan Agricultural University , Zhengzhou, China.
Gongzheng HuDepartment of Pharmacology and Toxicology, College of Veterinary Medicine, Henan Agricultural University , Zhengzhou, China.
Yajun ZhaiDepartment of Pharmacology and Toxicology, College of Veterinary Medicine, Henan Agricultural University , Zhengzhou, China.
Tony VelkovDepartment of Pharmacology, Biodiscovery Institute, Monash University , Clayton, Victoria, Australia.
Hua WuDepartment of Pharmacology and Toxicology, College of Veterinary Medicine, Henan Agricultural University , Zhengzhou, China.ORCID 0000-0002-1301-3076
Henan Agricultural University · CNSouth China Agricultural University · CNHenan Institute of Science and Technology · CNMonash University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emergence and rapid spread of multi-drug-resistant (MDR) bacteria pose a serious threat to global healthcare. Although the synergistic effect of rafoxanide and colistin was reported, little is known regarding the potential mechanism of this synergy, particularly against chromosomal-mediated colistin-resistant

Indexed as

ColistinRafoxanideAdenosine TriphosphateAnimalsChromosomesHumansKlebsiella pneumoniaeReactive Oxygen SpeciesSwineAdenosine TriphosphateColistinRafoxanideReactive Oxygen Specieschromosomal-mediated colistin-resistant Klebsiella pneumoniaecolistin resistancerafoxanidereversing resistancetranscriptomic analysis

Identifiers

PMID37747188
PMCPMC10597454
OpenAlexW4387002200

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.